ENSDARG00000029204


Danio rerio

Features
Gene ID: ENSDARG00000029204
  
Biological name :tyrp1a
  
Synonyms : tyrosinase-related protein 1a / tyrp1a
  
Possible biological names infered from orthology : P07147 / P17643 / tyrosinase related protein 1 / TYRP1
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 74084203
Gene end: 74090168
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000050527
NCBI entrez gene - 100333145     See in Manteia.
RefSeq - XM_021478078
swissprot - F1QEC9
ZFIN ID - ZDB-GENE-070718-2
Ensembl - ENSDARG00000029204
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TYRP1ENSGALG00000015205Gallus gallus
 TYRP1ENSG00000107165Homo sapiens
 Tyrp1ENSMUSG00000005994Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tyrp1b / tyrosinase-related protein 1b / TYRP1* / P07147* / P17643* / tyrosinase related protein 1*ENSDARG0000005615170
dct / dopachrome tautomerase / P29812* / P40126* / L-dopachrome tautomerase *ENSDARG0000000600843
tyr / tyrosinase / P14679*ENSDARG0000003907738


Protein motifs (from Interpro)
Interpro ID Name
 IPR002227  Tyrosinase copper-binding domain
 IPR008922  Uncharacterised domain, di-copper centre
 IPR015559  Putative tyrosinase-like, Tyr-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003406 retinal pigment epithelium development IGI
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030318 melanocyte differentiation IGI
 biological_processGO:0032438 melanosome organization IMP
 biological_processGO:0043473 pigmentation IGI
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Melanin biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens structure , abnormal
lens reflectivity , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium brown , abnormal
retinal pigmented epithelium melanocyte decreased size , abnormal
retinal pigmented epithelium melanocyte deformed , abnormal
retinal pigmented epithelium manganese atom decreased amount , abnormal
retinal pigmented epithelium bromine atom decreased amount , abnormal
retinal pigmented epithelium calcium atom decreased amount , abnormal
retinal pigmented epithelium melanins brown , abnormal
retinal pigmented epithelium potassium atom decreased amount , abnormal
retinal pigmented epithelium zinc atom decreased amount , abnormal
retinal pigmented epithelium selenium atom decreased amount , abnormal
retinal pigmented epithelium barium atom decreased amount , abnormal
retinal pigmented epithelium strontium atom decreased amount , abnormal
retinal pigmented epithelium chemical homeostasis within retina disrupted , abnormal
retinal pigmented epithelium melanocyte absent , abnormal
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 ZFA:0001094 whole organism whole organism lacks parts or has fewer parts of type melanocyte , abnormal
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 ZFA:0001119 dermis dermis melanocyte decreased size , abnormal
dermis melanocyte deformed , abnormal
Show

 ZFA:0001463 melanophore stripe melanophore stripe has fewer parts of type melanocyte , abnormal
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 ZFA:0009091 melanocyte melanocyte brown , abnormal
melanocyte colorless , abnormal
melanocyte unpigmented , abnormal
melanocyte decreased amount , abnormal
melanocyte shape , abnormal
melanocyte melanosome decreased amount , abnormal
Show

 ZFA:0009249 melanoblast melanoblast cell maturation arrested , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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