ENSDARG00000030494


Danio rerio

Features
Gene ID: ENSDARG00000030494
  
Biological name :hfe2
  
Synonyms : hemochromatosis type 2 / hfe2
  
Possible biological names infered from orthology : hemochromatosis type 2 (juvenile) / Hemojuvelin / Q6ZVN8 / Q7TQ32
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 42883799
Gene end: 42894628
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000045599
Ensembl peptide - ENSDARP00000123796
NCBI entrez gene - 321932     See in Manteia.
RefSeq - NM_001045281
RefSeq Peptide - NP_001038746
swissprot - F8W533
swissprot - Q1JQE7
ZFIN ID - ZDB-GENE-030131-651
Ensembl - ENSDARG00000030494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HFE2ENSG00000168509Homo sapiens
 Hfe2ENSMUSG00000038403Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rgma / repulsive guidance molecule family member a / Q6PCX7* / Q96B86* / Repulsive guidance molecule A * / repulsive guidance molecule BMP co-receptor a*ENSDARG0000001224838
rgmd / RGM domain family, member DENSDARG0000003401337
rgmb / repulsive guidance molecule family member b / Q6NW40* / repulsive guidance molecule BMP co-receptor b*ENSDARG0000007932336


Protein motifs (from Interpro)
Interpro ID Name
 IPR009496  Repulsive guidance molecule, C-terminal
 IPR010536  Repulsive guidance molecule, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:0061053 somite development IMP
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane ISS
 cellular_componentGO:1990712 HFE-transferrin receptor complex IEA
 molecular_functionGO:0015026 coreceptor activity IBA
 molecular_functionGO:0036122 BMP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000123 liver liver decreased size , abnormal
Show

 ZFA:0000135 notochord notochord undulate , abnormal
Show

 ZFA:0000155 somite somite decreased thickness , abnormal
somite U-shaped , abnormal
Show

 ZFA:0001094 whole organism whole organism undulate , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr