ENSDARG00000031783


Danio rerio
cyclaseadcy8adenylateactivitynucleotidebiosyntheticprocessmembraneadenylylclass-guanylylconservedsignaltransductionaxonretinalganglioncellintracellularguanylatelyaseactivationpathwaydomainsitecampcgmpcyclicmidlinechoicepoint

Features
Gene ID: ENSDARG00000031783
  
Biological name :adcy8
  
Synonyms : adcy8 / adenylate cyclase 8 (brain)
  
Possible biological names infered from orthology : adenylate cyclase 8 / Adenylate cyclase type 8 / P40145 / P97490
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 42776224
Gene end: 42871286
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000120288
Ensembl peptide - ENSDARP00000123504
Ensembl peptide - ENSDARP00000082256
Ensembl peptide - ENSDARP00000114952
swissprot - B0S535
swissprot - B0S536
swissprot - F1QHU3
swissprot - F1QP02
ZFIN ID - ZDB-GENE-070912-197
Ensembl - ENSDARG00000031783
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADCY8ENSGALG00000030251Gallus gallus
 ADCY8ENSG00000155897Homo sapiens
 Adcy8ENSMUSG00000022376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:ch211-132f19.7ENSDARG0000004314155
si:dkey-206f10.1ENSDARG0000003283853
adcy6b / adenylate cyclase 6b / ADCY6* / O43306* / adenylate cyclase 6*ENSDARG0000002779742
adcy6a / adenylate cyclase 6a / ADCY6* / O43306* / adenylate cyclase 6*ENSDARG0000006144542
adcy5 / adenylate cyclase 5 / O95622* / P84309* / Adenylate cyclase type 5 *ENSDARG0000009134242
adcy1a / adenylate cyclase 1a / ADCY1* / Q08828* / O88444* / adenylate cyclase 1* / Adenylate cyclase type 1 *ENSDARG0000006902638
adcy2b / adenylate cyclase 2b (brain) / ADCY2* / Q08462* / adenylate cyclase 2*ENSDARG0000001458837
adcy7 / adenylate cyclase 7 / P51828* / P51829* / Adenylate cyclase type 7 *ENSDARG0000006007037
adcy3a / adenylate cyclase 3a / ADCY3* / O60266* / adenylate cyclase 3*ENSDARG0000007714537
adcy3b / adenylate cyclase 3b / ADCY3* / Q8VHH7* / O60266* / adenylate cyclase 3* / Adenylate cyclase type 3 *ENSDARG0000001743736
adcy2a / adenylate cyclase 2a / ADCY2* / Q08462* / adenylate cyclase 2*ENSDARG0000005839236
adcy1b / adenylate cyclase 1b / ADCY1* / Q08828* / O88444* / adenylate cyclase 1* / Adenylate cyclase type 1 *ENSDARG0000008863435
adcy9 / adenylate cyclase 9 / O60503* / P51830* / Adenylate cyclase type 9 *ENSDARG0000010086929
CR339059.1 / ADCY9* / O60503* / adenylate cyclase 9*ENSDARG0000010384713


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR009398  Adenylate cyclase, conserved domain
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase


Gene Ontology (GO)
nitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscell recognitionresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscell recognitionresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscell recognitionresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscell recognitionresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscell recognitionresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscell recognitionresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscell recognitionresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscell recognitionresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscell recognitionresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentanatomical structure developmentcellular developmental processnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processsmall molecule metabolic processorganic substance metabolic processcell communicationcellular response to stimuluscell recognitionresponse to external stimuluscellular component organizationresponse to chemicalmovement of cell or subcellular componentanatomical structure developmentcellular developmental processnitrogen nitrogen compound metabolic processbiosynthebiosynthetic processcellular cellular metabolic processprimary mprimary metabolic processsmall molsmall molecule metabolic processorganic sorganic substance metabolic processcell commcell communicationcellular cellular response to stimuluscell recocell recognitionresponse response to external stimuluscellular cellular component organizationresponse response to chemicalmovement movement of cell or subcellular componentanatomicaanatomical structure developmentcellular cellular developmental process
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activityorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingcyclase activitylyase activityorganic cyclic compound bindorganic cyclic compound bindingheterocyclic compound bindinheterocyclic compound bindingsmall molecule bindingsmall molecule bindingcyclase activitycyclase activitylyase activitylyase activity
cellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellmembraneprotein-containing complexcellcellmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0006171 cAMP biosynthetic process IEA
 biological_processGO:0006182 cGMP biosynthetic process IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0016199 axon midline choice point recognition IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0008074 guanylate cyclase complex, soluble IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity IEA
 molecular_functionGO:0004383 guanylate cyclase activity IBA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA


Pathways (from Reactome)
Pathway description
PKA activation
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (z) signalling events
CREB phosphorylation through the activation of Adenylate Cyclase
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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