Manteia

ENSDARG00000032161

Danio rerio

Features

Gene ID:	ENSDARG00000032161

Biological name :	srgap2

Synonyms :	B0S6J3 / SLIT-ROBO Rho GTPase activating protein 2 / srgap2

Possible biological names infered from orthology :	O75044 / P0DJJ0 / P0DMP2 / Q91Z67 / SLIT-ROBO Rho GTPase activating protein 2B / SLIT-ROBO Rho GTPase activating protein 2C / SRGAP2B / SRGAP2C

Species:	Danio rerio

Chr. number:	11
Strand:	-1
Band:
Gene start:	21405697
Gene end:	21586157

Corresponding Affymetrix probe sets:

Cross references:	Ensembl peptide - ENSDARP00000045390 Ensembl peptide - ENSDARP00000153532 Ensembl peptide - ENSDARP00000155791 swissprot - B0S6J3 ZFIN ID - ZDB-GENE-060915-2 Ensembl - ENSDARG00000032161

See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
	ENSGALG00000000816	Gallus gallus
O75044	ENSG00000266028	Homo sapiens
P0DJJ0	ENSG00000171943	Homo sapiens
P0DMP2	ENSG00000196369	Homo sapiens
Q91Z67	ENSMUSG00000026425	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
srgap1a / SLIT-ROBO Rho GTPase activating protein 1a / Q7Z6B7* / Q91Z69* / SRGAP1* / SLIT-ROBO Rho GTPase activating protein 1*	ENSDARG00000007461	62
srgap3 / SLIT-ROBO Rho GTPase activating protein 3 / O43295*	ENSDARG00000060309	57
srgap1b / SLIT-ROBO Rho GTPase activating protein 1b / Q7Z6B7* / Q91Z69* / SRGAP1* / SLIT-ROBO Rho GTPase activating protein 1*	ENSDARG00000045789	54
arhgap4b / Rho GTPase activating protein 4b / P98171* / ARHGAP4* / Rho GTPase activating protein 4*	ENSDARG00000015003	37
arhgap4a / Rho GTPase activating protein 4a / P98171* / ARHGAP4* / Rho GTPase activating protein 4*	ENSDARG00000039265	31
arhgap17a / Rho GTPase activating protein 17a / Q68EM7* / ARHGAP17* / Rho GTPase activating protein 17*	ENSDARG00000020488	11
ARHGAP22 / si:dkey-191m6.4 / Q7Z5H3* / Q8BL80* / Rho GTPase activating protein 22*	ENSDARG00000076434	11
arhgap24 / Rho GTPase activating protein 24 / Q8C4V1* / Q8N264*	ENSDARG00000100973	11
si:ch211-114m9.1 / Q17R89* / ARHGAP44* / Rho GTPase activating protein 44*	ENSDARG00000102424	11
arhgap25 / Rho GTPase activating protein 25 / P42331* / Q8BYW1*	ENSDARG00000061784	10
arhgap44 / Rho GTPase activating protein 44 / Q17R89* / Q5SSM3*	ENSDARG00000104549	10
arhgap17b / Rho GTPase activating protein 17b / Q3UIA2* / Q68EM7* / ARHGAP17* / Rho GTPase activating protein 17*	ENSDARG00000062263	9
sh3bp1 / SH3-domain binding protein 1 / Q9Y3L3* / P55194* / Z83844.3* / AL592169.1*	ENSDARG00000078119	9
si:ch211-247j9.1	ENSDARG00000079283	8
arhgap22 / Rho GTPase activating protein 22	ENSDARG00000021255	6

Protein motifs (from Interpro)

Interpro ID	Name
IPR000198	Rho GTPase-activating protein domain
IPR001060	FCH domain
IPR001452	SH3 domain
IPR008936	Rho GTPase activation protein
IPR027267	AH/BAR domain superfamily
IPR030252	SLIT-ROBO Rho GTPase-activating protein 2
IPR031160	F-BAR domain
IPR035648	srGAP1/2/3, SH3 domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007399	nervous system development	IEA
biological_process	GO:0030336	negative regulation of cell migration	IBA
biological_process	GO:0043547	positive regulation of GTPase activity	ISS
biological_process	GO:0046847	filopodium assembly	ISS
biological_process	GO:0048812	neuron projection morphogenesis	ISS
biological_process	GO:0051014	actin filament severing	ISS
biological_process	GO:0060996	dendritic spine development	ISS
biological_process	GO:2001223	negative regulation of neuron migration	ISS
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISS
cellular_component	GO:0005886	plasma membrane	ISS
cellular_component	GO:0014069	postsynaptic density	ISS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030027	lamellipodium	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0043197	dendritic spine	IEA
cellular_component	GO:0044327	dendritic spine head	ISS
cellular_component	GO:0045202	synapse	IEA
cellular_component	GO:0045211	postsynaptic membrane	ISS
cellular_component	GO:0045335	phagocytic vesicle	ISS
molecular_function	GO:0005096	GTPase activator activity	IBA
molecular_function	GO:0042803	protein homodimerization activity	ISS
molecular_function	GO:0048365	Rac GTPase binding	ISS

Pathways (from Reactome)

Pathway description

Rho GTPase cycle

RHO GTPases Activate Formins

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000037746	actb1 / Q7ZVI7 / actin, beta 1 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...	/ complex / reaction
ENSDARG00000037870	actb2 / Q7ZVF9 / actin, beta 2 / ACTB* / ACTG1* / POTEJ* / P60709* / P0CG39* / P60710* / P63260* / P63261* / actin beta* / actin gamma 1* / POTE ankyrin domain family member J* / Actin, cyt...	/ complex / reaction
ENSDARG00000055713	fmnl1a / formin-like 1a / FMNL1* / O95466* / Q9JL26* / formin like 1* / Formin-like protein 1 *	/ complex / reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr