ENSDARG00000033726


Danio rerio
signalingtshbabetasubunithormonegonadotropinglycoproteinreceptorpathwayactivityextracellularconservedsitecystine-knotcytokineg-proteincoupledcell-cellhormone-mediatedregulationregionspacecytoplasmhormonesligand-bindingreceptorsgalphassignallingevents

Features
Gene ID: ENSDARG00000033726
  
Biological name :tshba
  
Synonyms : thyroid stimulating hormone, beta subunit, a / tshba
  
Possible biological names infered from orthology : P01222 / thyroid stimulating hormone beta / thyroid stimulating hormone, beta subunit / TSHB
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 49081141
Gene end: 49085296
  
Corresponding Affymetrix probe sets: Dr.24255.1.S1_at (Zebrafish Array)   NM_181494_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000108432
Ensembl peptide - ENSDARP00000154219
Ensembl peptide - ENSDARP00000049999
NCBI entrez gene - 353223     See in Manteia.
RefSeq - NM_181494
RefSeq Peptide - NP_852471
swissprot - B3DJU0
ZFIN ID - ZDB-GENE-030513-3
Ensembl - ENSDARG00000033726
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TSHBENSGALG00000002550Gallus gallus
 TSHBENSG00000134200Homo sapiens
 TshbENSMUSG00000027857Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CU929146.1 / TSHB* / P01222* / thyroid stimulating hormone beta* / thyroid stimulating hormone, beta subunit*ENSDARG0000011011034
lhb / luteinizing hormone, beta polypeptide / CGB2* / CGB3* / CGB1* / CGB7* / CGB8* / CGB5* / A6NKQ9* / P01229* / P0DN86* / P0DN87* / AC008687.1* / chorionic gonadotropin beta subunit 2* / ...ENSDARG0000009936326
fshb / follicle stimulating hormone, beta polypeptide / P01225* / Q60687* / Follitropin subunit beta * / follicle stimulating hormone beta subunit*ENSDARG0000001084121


Protein motifs (from Interpro)
Interpro ID Name
 IPR001545  Gonadotropin, beta subunit
 IPR006208  Glycoprotein hormone subunit beta
 IPR018245  Gonadotropin, beta subunit, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
cell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcell communicationcellular response to stimulucellular response to stimulusresponse to endogenous stimuresponse to endogenous stimulusresponse to chemicalresponse to chemicalregulation of molecular funcregulation of molecular function
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regionextracellular regioncellcell
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005179 hormone activity IBA


Pathways (from Reactome)
Pathway description
Glycoprotein hormones
Hormone ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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