ENSGALG00000002550


Gallus gallus
signalingTSHBbetasubunithormonegonadotropinglycoproteinreceptorpathwayactivityextracellularconservedsitecystine-knotcytokineg-proteincoupledcell-cellhormone-mediatedregulationregionspacecytoplasmhormonesthyroxinebiosynthesisligand-bindingreceptorsgalphas

Features
Gene ID: ENSGALG00000002550
  
Biological name :TSHB
  
Synonyms : O57340 / Thyrotropin subunit beta / TSHB
  
Possible biological names infered from orthology : P01222 / thyroid stimulating hormone beta / thyroid stimulating hormone, beta subunit
  
Species: Gallus gallus
  
Chr. number: 26
Strand: 1
Band:
Gene start: 3979888
Gene end: 3982784
  
Corresponding Affymetrix probe sets: Gga.551.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000004015
NCBI entrez gene - 395937     See in Manteia.
RefSeq - XM_015298896
RefSeq - NM_205063
RefSeq - XM_015298895
RefSeq Peptide - NP_990394
swissprot - O57340
swissprot - A5YW28
Ensembl - ENSGALG00000002550
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU929146.1ENSDARG00000110110Danio rerio
 tshbaENSDARG00000033726Danio rerio
 TSHBENSG00000134200Homo sapiens
 TshbENSMUSG00000027857Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FSHB / follicle stimulating hormone beta subunit / P01225* / Q60687* / Follitropin subunit beta *ENSGALG0000001214031


Protein motifs (from Interpro)
Interpro ID Name
 IPR001545  Gonadotropin, beta subunit
 IPR006208  Glycoprotein hormone subunit beta
 IPR018245  Gonadotropin, beta subunit, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
cell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalregulation of molecular functioncell communicationcell communicationcellular response to stimulucellular response to stimulusresponse to endogenous stimuresponse to endogenous stimulusresponse to chemicalresponse to chemicalregulation of molecular funcregulation of molecular function
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regionextracellular regioncellcell
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005179 hormone activity IBA


Pathways (from Reactome)
Pathway description
Glycoprotein hormones
Thyroxine biosynthesis
Hormone ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010572 TSHR / thyrotropin receptor isoform 2 precursor / P16473* / P47750* / thyroid stimulating hormone receptor*  / complex / reaction
 ENSGALG00000015824 CGA / glycoprotein hormones, alpha polypeptide / P01215* / P01216* / Glycoprotein hormones alpha chain *  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr