ENSDARG00000033735


Danio rerio

Features
Gene ID: ENSDARG00000033735
  
Biological name :ncf1
  
Synonyms : ncf1 / neutrophil cytosolic factor 1
  
Possible biological names infered from orthology : Neutrophil cytosol factor 1 / P14598 / Q09014
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 61432541
Gene end: 61445697
  
Corresponding Affymetrix probe sets: Dr.2973.1.A1_at (Zebrafish Array)   NM_001030071_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000050897
NCBI entrez gene - 378966     See in Manteia.
RefSeq - NM_001030071
RefSeq Peptide - NP_001025242
swissprot - A2BFP2
ZFIN ID - ZDB-GENE-031006-6
Ensembl - ENSDARG00000033735
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NCF1ENSGALG00000001189Gallus gallus
 NCF1ENSG00000158517Homo sapiens
 Ncf1ENSMUSG00000015950Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sh3pxd2b / SH3 and PX domains 2B / A1X283* / A2AAY5* / SH3 and PX domain-containing protein 2B *ENSDARG0000010325130
noxo1a / NADPH oxidase organizer 1a / NOXO1* / Q8NFA2* / NADPH oxidase organizer 1*ENSDARG0000004129425
noxo1b / NADPH oxidase organizer 1b / NOXO1* / Q8NFA2* / Q8VCM2* / NADPH oxidase organizer 1*ENSDARG0000005637424
sh3pxd2aa / SH3 and PX domains 2Aa / Q5TCZ1* / O89032* / SH3PXD2A* / SH3 and PX domains 2A* / SH3 and PX domain-containing protein 2A *ENSDARG0000006014824
sh3pxd2ab / SH3 and PX domains 2Ab / Q5TCZ1* / O89032* / SH3PXD2A* / SH3 and PX domains 2A* / SH3 and PX domain-containing protein 2A *ENSDARG0000006175819


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR001655  Neutrophil cytosol factor 1
 IPR001683  Phox homologous domain
 IPR015039  NADPH oxidase subunit p47Phox, C-terminal
 IPR032136  Neutrophil cytosol factor 1, C-terminal
 IPR034909  Neutrophil cytosol factor 1, PX domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IBA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0045730 respiratory burst IMP
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:0055114 oxidation-reduction process IBA
 biological_processGO:0071800 podosome assembly IBA
 cellular_componentGO:0002102 podosome IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016176 superoxide-generating NADPH oxidase activator activity IBA
 molecular_functionGO:0035091 phosphatidylinositol binding IBA


Pathways (from Reactome)
Pathway description
ROS, RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism dead , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr