ENSDARG00000037195


Danio rerio

Features
Gene ID: ENSDARG00000037195
  
Biological name :tshr
  
Synonyms : thyroid stimulating hormone receptor / tshr
  
Possible biological names infered from orthology : P16473 / P47750
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 6035427
Gene end: 6079923
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000054085
NCBI entrez gene - 560609     See in Manteia.
RefSeq - NM_001145763
RefSeq Peptide - NP_001139235
swissprot - F1Q981
ZFIN ID - ZDB-GENE-110524-4
Ensembl - ENSDARG00000037195
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TSHRENSGALG00000010572Gallus gallus
 TSHRENSG00000165409Homo sapiens
 TshrENSMUSG00000020963Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lhcgr / luteinizing hormone/choriogonadotropin receptor / P22888* / P30730* / AC073082.1* / Lutropin-choriogonadotropic hormone receptor *ENSDARG0000002608142
fshr / follicle stimulating hormone receptor / P23945* / P35378*ENSDARG0000007149442
lgr4 / E7FE13 / leucine-rich repeat containing G protein-coupled receptor 4 / A2ARI4* / Q9BXB1*ENSDARG0000006054221
rxfp2b / relaxin/insulin-like family peptide receptor 2b / RXFP2* / Q91ZZ5* / Q8WXD0* / Relaxin receptor 2 * / relaxin/insulin like family peptide receptor 2*ENSDARG0000001966018
rxfp2l / relaxin/insulin-like family peptide receptor 2, likeENSDARG0000006873118
rxfp1 / relaxin/insulin-like family peptide receptor 1 / Q6R6I7* / Q9HBX9* / Relaxin receptor 1 *ENSDARG0000009007118
rxfp2a / relaxin/insulin-like family peptide receptor 2a / RXFP2* / Q91ZZ5* / Q8WXD0* / Relaxin receptor 2 * / relaxin/insulin like family peptide receptor 2*ENSDARG0000003282017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001611  Leucine-rich repeat
 IPR002131  Glycoprotein hormone receptor family
 IPR002274  Thyrotropin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily
 IPR034298  TSH/LHCG/FSH receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007190 activation of adenylate cyclase activity IBA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0038194 thyroid-stimulating hormone signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004996 thyroid-stimulating hormone receptor activity IDA
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IBA
 molecular_functionGO:0016500 protein-hormone receptor activity IEA


Pathways (from Reactome)
Pathway description
Hormone ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000622 barbel barbel absent , abnormal
Show

 ZFA:0000737 cranium cranium deformed , abnormal
Show

 ZFA:0001072 thyroid follicle thyroid follicle decreased size , abnormal
thyroid follicle decreased amount , abnormal
thyroid follicle poorly differentiated , abnormal
Show

 ZFA:0001273 ventral mandibular arch ventral mandibular arch hypertrophic , abnormal
Show

 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
melanocyte increased amount , abnormal
Show

 ZFA:0009198 xanthophore xanthophore increased amount , abnormal
xanthophore decreased amount , abnormal
xanthophore cell projection decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr