ENSDARG00000060542


Danio rerio

Features
Gene ID: ENSDARG00000060542
  
Biological name :lgr4
  
Synonyms : E7FE13 / leucine-rich repeat containing G protein-coupled receptor 4 / lgr4
  
Possible biological names infered from orthology : A2ARI4 / Q9BXB1
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 32369026
Gene end: 32460223
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000149657
Ensembl peptide - ENSDARP00000137036
NCBI entrez gene - 558825     See in Manteia.
RefSeq - NM_001353862
RefSeq - XM_021477865
RefSeq Peptide - NP_001340791
swissprot - E7FE13
ZFIN ID - ZDB-GENE-111013-1
Ensembl - ENSDARG00000060542
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LGR4ENSGALG00000040834Gallus gallus
 LGR4ENSG00000205213Homo sapiens
 Lgr4ENSMUSG00000050199Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lhcgr / luteinizing hormone/choriogonadotropin receptor / P22888* / P30730* / AC073082.1* / Lutropin-choriogonadotropic hormone receptor *ENSDARG0000002608117
tshr / thyroid stimulating hormone receptor / P16473*ENSDARG0000003719517
fshr / follicle stimulating hormone receptor / P23945* / P35378*ENSDARG0000007149416
rxfp2b / relaxin/insulin-like family peptide receptor 2b / RXFP2* / Q91ZZ5* / Q8WXD0* / Relaxin receptor 2 * / relaxin/insulin like family peptide receptor 2*ENSDARG0000001966014
rxfp2a / relaxin/insulin-like family peptide receptor 2a / RXFP2* / Q91ZZ5* / Q8WXD0* / Relaxin receptor 2 * / relaxin/insulin like family peptide receptor 2*ENSDARG0000003282014
rxfp2l / relaxin/insulin-like family peptide receptor 2, likeENSDARG0000006873114
rxfp1 / relaxin/insulin-like family peptide receptor 1 / Q6R6I7* / Q9HBX9* / Relaxin receptor 1 *ENSDARG0000009007114


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001611  Leucine-rich repeat
 IPR002131  Glycoprotein hormone receptor family
 IPR003591  Leucine-rich repeat, typical subtype
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030282 bone mineralization ISS
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway ISS
 biological_processGO:0046849 bone remodeling ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050710 negative regulation of cytokine secretion ISS
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity ISS
 molecular_functionGO:0016500 protein-hormone receptor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000079570 rspo2 / R-spondin 2 / Q6UXX9* / Q8BFU0* / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA.*  / complex / reaction
 ENSDARG00000104340 rspo1 / Q6DHR0 / R-spondin 1 / Q2MKA7*  / complex / reaction






 

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