ENSDARG00000039516


Danio rerio

Features
Gene ID: ENSDARG00000039516
  
Biological name :c8a
  
Synonyms : c8a / complement component 8, alpha polypeptide
  
Possible biological names infered from orthology : complement C8 alpha chain / Complement component C8 alpha chain / P07357 / Q8K182
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 1486822
Gene end: 1499584
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000115822
Ensembl peptide - ENSDARP00000119169
NCBI entrez gene - 445102     See in Manteia.
swissprot - F1Q6F3
swissprot - F1R901
ZFIN ID - ZDB-GENE-040801-239
Ensembl - ENSDARG00000039516
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 C8AENSGALG00000010850Gallus gallus
 C8AENSG00000157131Homo sapiens
 C8aENSMUSG00000035031Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
c6 / complement component 6 / P13671* / complement C6*ENSDARG0000005711327
c7b / complement component 7b / C7* / P10643* / complement C7* / complement component 7*ENSDARG0000005712127
c6 / complement component 6 / P13671* / complement C6*ENSDARG0000009305227
c9 / complement component 9 / P02748* / complement C9*ENSDARG0000001631926
c8b / complement component 8, beta polypeptide / P07358* / complement C8 beta chain*ENSDARG0000003951726
c7a / complement component 7a / C7* / P10643* / complement C7* / complement component 7*ENSDARG0000004217224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001862  Membrane attack complex component/perforin/complement C9
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR013032  EGF-like, conserved site
 IPR020863  Membrane attack complex component/perforin domain, conserved site
 IPR020864  Membrane attack complex component/perforin (MACPF) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006956 complement activation IEA
 cellular_componentGO:0005579 membrane attack complex IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Terminal pathway of complement
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000032098 c8g / complement component 8, gamma polypeptide / Q8VCG4* / P07360* / complement C8 gamma chain* / Complement component C8 gamma chain *  / complex
 ENSDARG00000039517 c8b / complement component 8, beta polypeptide / P07358* / complement C8 beta chain*  / complex
 ENSDARG00000021004 c5 / complement component 5 / P01031* / complement C5*  / reaction / complex
 ENSDARG00000057121 c7b / complement component 7b / C7* / P10643* / complement C7* / complement component 7*  / complex / reaction
 ENSDARG00000053831 vtnb / vitronectin b / VTN* / P04004* / P29788* / AC002094.3* / vitronectin*  / complex / reaction
 ENSDARG00000016319 c9 / complement component 9 / P02748* / complement C9*  / complex / reaction






 

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