ENSDARG00000042934


Danio rerio

Features
Gene ID: ENSDARG00000042934
  
Biological name :ctgfa
  
Synonyms : connective tissue growth factor a / ctgfa
  
Possible biological names infered from orthology : connective tissue growth factor / CTGF / P29268 / P29279
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 25340814
Gene end: 25343490
  
Corresponding Affymetrix probe sets: Dr.10431.1.S1_at (Zebrafish Array)   NM_001015041_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000063027
NCBI entrez gene - 321449     See in Manteia.
RefSeq - NM_001015041
RefSeq Peptide - NP_001015041
swissprot - Q5RI33
ZFIN ID - ZDB-GENE-030131-102
Ensembl - ENSDARG00000042934
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTGFENSGALG00000037402Gallus gallus
 CTGFENSG00000118523Homo sapiens
 CtgfENSMUSG00000019997Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ctgfb / connective tissue growth factor bENSDARG0000010429255
cyr61 / cysteine-rich, angiogenic inducer, 61 / O00622*ENSDARG0000002306243
wisp1a / WNT1 inducible signaling pathway protein 1a / WISP1* / O95388* / O54775* / WNT1 inducible signaling pathway protein 1*ENSDARG0000005433143
wisp1b / WNT1 inducible signaling pathway protein 1b / WISP1* / O95388* / O54775* / WNT1 inducible signaling pathway protein 1*ENSDARG0000007668542
si:ch211-106h11.3ENSDARG0000002736041
wisp2 / WNT1 inducible signaling pathway protein 2 / O76076*ENSDARG0000007788240
cyr61l1 / cysteine-rich, angiogenic inducer 61 like 1ENSDARG0000003542239
cyr61l2 / cysteine-rich, angiogenic inducer, 61 like 2ENSDARG0000009998539
wisp3 / WNT1 inducible signaling pathway protein 3 / D3Z5L9* / O95389*ENSDARG0000007104835


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR006207  Cystine knot, C-terminal
 IPR006208  Glycoprotein hormone subunit beta
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR012395  IGFBP-related, CNN


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0030903 notochord development IMP
 biological_processGO:0031099 regeneration IMP
 biological_processGO:0043009 chordate embryonic development IMP
 biological_processGO:0060548 negative regulation of cell death IBA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005178 integrin binding IBA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008201 heparin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm anterior region apoptotic , abnormal
endoderm apoptotic process increased occurrence , abnormal
endoderm antero-medial region decreased object quality , abnormal
Show

 ZFA:0000075 spinal cord spinal cord regeneration decreased process quality , abnormal
spinal cord axon regeneration decreased occurrence , abnormal
Show

 ZFA:0000107 eye eye aplastic , abnormal
Show

 ZFA:0000114 heart heart split bilaterally , abnormal
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 ZFA:0000135 notochord notochord deformed , abnormal
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 ZFA:0000155 somite somite morphology , abnormal
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 ZFA:0000360 heart tube heart tube split bilaterally , abnormal
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 ZFA:0001094 whole organism whole organism hypoplastic , abnormal
whole organism edematous , abnormal
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 ZFA:0001117 post-vent region post-vent region shape , abnormal
post-vent region structure , abnormal
post-vent region decreased length , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin aplastic , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
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 ZFA:0005147 regenerating tissue regenerating tissue glial cell proliferation decreased amount , abnormal
regenerating tissue glial cell decreased amount , abnormal
Show

 ZFA:0005490 myocardial precursor myocardial precursor mislocalised laterally , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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