ENSDARG00000043130


Danio rerio

Features
Gene ID: ENSDARG00000043130
  
Biological name :notch2
  
Synonyms : notch2
  
Possible biological names infered from orthology : Q04721
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 19548985
Gene end: 19619792
  
Corresponding Affymetrix probe sets: Dr.604.1.S1_at (Zebrafish Array)   Dr.604.1.S2_at (Zebrafish Array)   Dr.604.2.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000112112
NCBI entrez gene - 58065     See in Manteia.
RefSeq - NM_001115094
RefSeq Peptide - NP_001108566
swissprot - F1RCH4
ZFIN ID - ZDB-GENE-000329-4
Ensembl - ENSDARG00000043130
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOTCH2ENSGALG00000002922Gallus gallus
 NOTCH2ENSG00000134250Homo sapiens
 Notch2ENSMUSG00000027878Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
notch3 / Q9UM47*ENSDARG0000005213950
notch1b / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000005209449
notch1a / NOTCH1* / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSDARG0000010355449
jag1b / jagged 1b / JAG1* / P78504* / Q9QXX0* / jagged 1* / Protein jagged-1 *ENSDARG0000001316814
jag2a / jagged 2a / JAG2* / Q9Y219* / jagged 2*ENSDARG0000001424614
jag2b / jagged 2b / JAG2* / Q9QYE5* / Q9Y219* / jagged 2* / Protein jagged-2 *ENSDARG0000002138914
jag1a / jagged 1a / JAG1* / P78504* / jagged 1*ENSDARG0000003028914
sned1 / sushi, nidogen and EGF-like domains 1 / Q8TER0*ENSDARG0000004443314
dla / deltaA / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG000000107918
dld / deltaD / DLL1* / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSDARG000000202198
si:ch73-281k2.5 / NOTCH2* / Q04721*ENSDARG000001043298
dlc / deltaCENSDARG000000023367
dlb / deltaB / O57409ENSDARG000000042327
dll4 / delta-like 4 (Drosophila) / Q9JI71* / Q9NR61* / Delta-like protein 4 * / delta like canonical Notch ligand 4*ENSDARG000000704257


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000800  Notch domain
 IPR001881  EGF-like calcium-binding domain
 IPR002110  Ankyrin repeat
 IPR008297  Notch
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010660  Notch, NOD domain
 IPR011656  Notch, NODP domain
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR022336  Neurogenic locus Notch 2
 IPR024600  Domain of unknown function DUF3454, notch


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IGI
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0042246 tissue regeneration IEP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0050793 regulation of developmental process IEA
 biological_processGO:0060325 face morphogenesis IGI
 biological_processGO:0060351 cartilage development involved in endochondral bone morphogenesis IGI
 biological_processGO:1990798 pancreas regeneration IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
NOTCH2 intracellular domain regulates transcription
NOTCH2 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000250 opercle opercle curved , abnormal
opercle decreased width , abnormal
Show

 ZFA:0001260 endocrine pancreas endocrine pancreas decreased size , abnormal
endocrine pancreas decreased distribution , abnormal
Show

 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage truncated , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage elongated , abnormal
hyosymplectic cartilage deformed , abnormal
Show

 ZFA:0005110 thoracic duct thoracic duct absent , abnormal
thoracic duct wholeness , abnormal
Show

 ZFA:0009102 pancreatic B cell pancreatic B cell decreased amount , abnormal
pancreatic B cell decreased area , abnormal
pancreatic B cell regeneration decreased rate , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000003398 rbpja / recombination signal binding protein for immunoglobulin kappa J region a / RBPJ* / Q06330* / recombination signal binding protein for immunoglobulin kappa J region*  / complex / reaction
 ENSDARG00000043130 notch2 / Q04721*  / complex
 ENSDARG00000104329 si:ch73-281k2.5 / NOTCH2* / Q04721*  / complex
 ENSDARG00000052091 rbpjb / recombination signal binding protein for immunoglobulin kappa J region b / RBPJ* / Q06330* / P31266* / Recombining binding protein suppressor of hairless * / recombination signal bi...  / complex / reaction
 ENSDARG00000076466 maml1 / mastermind-like transcriptional coactivator 1 / Q6T264* / Q92585* / Mastermind-like protein 1 *  / complex / reaction
 ENSDARG00000079552 maml3 / mastermind-like transcriptional coactivator 3 / Q96JK9*  / complex / reaction






 

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