ENSDARG00000043531


Danio rerio

Features
Gene ID: ENSDARG00000043531
  
Biological name :jun
  
Synonyms : jun / Jun proto-oncogene, AP-1 transcription factor subunit
  
Possible biological names infered from orthology : jun proto-oncogene / P05412 / P05627
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 15552657
Gene end: 15554606
  
Corresponding Affymetrix probe sets: Dr.7608.1.A1_at (Zebrafish Array)   Dr.7608.2.S1_at (Zebrafish Array)   NM_199987_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000063911
NCBI entrez gene - 335916     See in Manteia.
RefSeq - NM_199987
RefSeq Peptide - NP_956281
swissprot - Q6NZT5
ZFIN ID - ZDB-GENE-030131-7859
Ensembl - ENSDARG00000043531
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JUNENSGALG00000010870Gallus gallus
 JUNENSG00000177606Homo sapiens
 JunENSMUSG00000052684Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
junba / JunB proto-oncogene, AP-1 transcription factor subunit a / JUNB* / P09450* / P17275* / Transcription factor jun-B * / JunB proto-oncogene, AP-1 transcription factor subunit*ENSDARG0000007437851
jund / JunD proto-oncogene, AP-1 transcription factor subunit / P15066* / P17535* / Transcription factor jun-D *ENSDARG0000006785049
junbb / JunB proto-oncogene, AP-1 transcription factor subunit b / JUNB* / P09450* / P17275* / Transcription factor jun-B * / JunB proto-oncogene, AP-1 transcription factor subunit*ENSDARG0000010477349
june / JunE proto-oncogene, AP-1 transcription factor subunitENSDARG0000010409046


Protein motifs (from Interpro)
Interpro ID Name
 IPR002112  Transcription factor Jun
 IPR004827  Basic-leucine zipper domain
 IPR005643  Jun-like transcription factor
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR015558  Transcription Factor c-Jun/v-Jun


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development IGI
 biological_processGO:0009314 response to radiation IBA
 biological_processGO:0009612 response to mechanical stimulus IBA
 biological_processGO:0010941 regulation of cell death IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug IBA
 biological_processGO:0045597 positive regulation of cell differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0046686 response to cadmium ion IEP
 biological_processGO:0051591 response to cAMP IBA
 biological_processGO:0051597 response to methylmercury IDA
 biological_processGO:0051726 regulation of cell cycle IBA
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005667 transcription factor complex IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0008013 beta-catenin binding IMP
 molecular_functionGO:0008134 transcription factor binding IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000079 telencephalon telencephalon increased size , abnormal
Show

 ZFA:0001094 whole organism whole organism wholly anterioralized , abnormal
Show

 ZFA:0001114 head head increased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased size , abnormal
Show

 ZFA:0009065 endothelial cell endothelial cell apoptotic process increased occurrence , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000031683 fosab / v-fos FBJ murine osteosarcoma viral oncogene homolog Ab / FOS* / P01100* / P01101* / Proto-onco c-Fos * / Fos proto-oncogene, AP-1 transcription factor subunit*  / complex / reaction
 ENSDARG00000023903 atf2 / activating transcription factor 2 / P15336* / P16951* / Cyclic AMP-dependent transcription factor ATF-2 *  / complex / reaction
 ENSDARG00000077364 mapk9 / mitogen-activated protein kinase 9 / P45984* / Q9WTU6*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr