ENSDARG00000044356


Danio rerio

Features
Gene ID: ENSDARG00000044356
  
Biological name :tp63
  
Synonyms : tp63 / tumor protein p63
  
Possible biological names infered from orthology : O88898 / Q9H3D4 / transformation related protein 63 / Trp63
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 28795780
Gene end: 28914225
  
Corresponding Affymetrix probe sets: Dr.19227.1.S1_at (Zebrafish Array)   Dr.19227.3.S1_a_at (Zebrafish Array)   NM_152986_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000108362
Ensembl peptide - ENSDARP00000155750
Ensembl peptide - ENSDARP00000140981
Ensembl peptide - ENSDARP00000132905
Ensembl peptide - ENSDARP00000065134
Ensembl peptide - ENSDARP00000065136
Ensembl peptide - ENSDARP00000106582
Ensembl peptide - ENSDARP00000107767
NCBI entrez gene - 260407     See in Manteia.
RefSeq - NM_152248
RefSeq - NM_152986
RefSeq Peptide - NP_689454
RefSeq Peptide - NP_694518
swissprot - F1QLJ1
swissprot - Q6DG24
swissprot - Q8JFE3
swissprot - E9QG65
swissprot - A0A0R4IZ80
swissprot - A0A0R4IHL8
swissprot - F1QKD5
ZFIN ID - ZDB-GENE-030819-1
Ensembl - ENSDARG00000044356
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TP63ENSGALG00000007324Gallus gallus
 TP63ENSG00000073282Homo sapiens
 Trp63ENSMUSG00000022510Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tp73 / tumor protein p73 / Trp73* / Q9JJP2* / O15350* / transformation related protein 73*ENSDARG0000001795352
tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*ENSDARG0000003555927


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002117  p53 tumour suppressor family
 IPR008967  p53-like transcription factor, DNA-binding
 IPR010991  p53, tetramerisation domain
 IPR011615  p53, DNA-binding domain
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032645  Tumour protein p63


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010165 response to X-ray IBA
 biological_processGO:0010332 response to gamma radiation IBA
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IBA
 biological_processGO:0032502 developmental process IEA
 biological_processGO:0034644 cellular response to UV IBA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
 biological_processGO:0043066 negative regulation of apoptotic process IBA
 biological_processGO:0043523 regulation of neuron apoptotic process IBA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0048730 epidermis morphogenesis IMP
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0030425 dendrite IBA
 molecular_functionGO:0002039 p53 binding IBA
 molecular_functionGO:0003677 DNA binding IPI
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003684 damaged DNA binding IBA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001185 periderm periderm cell decreased amount , abnormal
Show

 ZFA:0005792 jaw flap jaw flap breeding tubercle decreased size , abnormal
Show

 ZFA:0005798 jaw row breeding tubercle jaw row breeding tubercle decreased size , abnormal
jaw row breeding tubercle decreased amount , abnormal
Show

 ZFA:0009041 peridermal cell peridermal cell increased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr