ENSDARG00000052113


Danio rerio

Features
Gene ID: ENSDARG00000052113
  
Biological name :hexa
  
Synonyms : hexa / hexosaminidase A (alpha polypeptide)
  
Possible biological names infered from orthology : AC009690.1 / Beta-hexosaminidase subunit alpha / hexosaminidase subunit alpha / P06865 / P29416
  
Species: Danio rerio
  
Chr. number: 25
Strand: 1
Band:
Gene start: 22216723
Gene end: 22241312
  
Corresponding Affymetrix probe sets: Dr.17343.1.S1_at (Zebrafish Array)   NM_001017763_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000051290
NCBI entrez gene - 550460     See in Manteia.
RefSeq - NM_001017763
RefSeq Peptide - NP_001017763
swissprot - F1RDQ5
ZFIN ID - ZDB-GENE-050417-283
Ensembl - ENSDARG00000052113
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HEXAENSGALG00000043828Gallus gallus
 AC009690.1ENSG00000260729Homo sapiens
 HEXAENSG00000213614Homo sapiens
 HexaENSMUSG00000025232Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hexb / hexosaminidase B (beta polypeptide) / P07686* / P20060* / hexosaminidase subunit beta* / Beta-hexosaminidase subunit beta *ENSDARG0000003436855


Protein motifs (from Interpro)
Interpro ID Name
 IPR015883  Glycoside hydrolase family 20, catalytic domain
 IPR017853  Glycoside hydrolase superfamily
 IPR025705  Beta-hexosaminidase
 IPR029018  Beta-hexosaminidase-like, domain 2
 IPR029019  Beta-hexosaminidase, eukaryotic type, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004563 beta-N-acetylhexosaminidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0102148 N-acetyl-beta-D-galactosaminidase activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism
Keratan sulfate degradation
CS/DS degradation
Hyaluronan uptake and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009141 macrophage macrophage morphology , abnormal
macrophage lysosome accumulation macrophage , abnormal
macrophage myeloid leukocyte migration process quality , abnormal
macrophage myeloid leukocyte migration decreased process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000088439 gm2a / GM2 ganglioside activator / P17900*  / reaction
 ENSDARG00000107431 LO018208.1 / GM2A* / P17900* / GM2 ganglioside activator*  / reaction
 ENSDARG00000034368 hexb / hexosaminidase B (beta polypeptide) / P07686* / P20060* / hexosaminidase subunit beta* / Beta-hexosaminidase subunit beta *  / complex






 

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