ENSDARG00000052150


Danio rerio

Features
Gene ID: ENSDARG00000052150
  
Biological name :pbx4
  
Synonyms : pbx4 / pre-B-cell leukemia transcription factor 4
  
Possible biological names infered from orthology : Mus musculus pre B cell leukemia homeobox 4 (Pbx4), transcript variant 4, mRNA. / PBX homeobox 4 / Q99NE9 / Q9BYU1
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 52999962
Gene end: 53076469
  
Corresponding Affymetrix probe sets: Dr.4926.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000095454
Ensembl peptide - ENSDARP00000129739
NCBI entrez gene - 30728     See in Manteia.
swissprot - Q9PW77
swissprot - X1WHM6
ZFIN ID - ZDB-GENE-000201-18
Ensembl - ENSDARG00000052150
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PBX4ENSG00000105717Homo sapiens
 Pbx4ENSMUSG00000031860Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pbx1a / pre-B-cell leukemia homeobox 1a / PBX1* / P41778* / P40424* / PBX homeobox 1* / Pre-B-cell leukemia transcription factor 1 *ENSDARG0000010049479
pbx1b / pre-B-cell leukemia homeobox 1b / PBX1* / P40424* / PBX homeobox 1*ENSDARG0000010113179
pbx3b / pre-B-cell leukemia homeobox 3b / PBX3* / P40426* / O35317* / PBX homeobox 3* / Pre-B-cell leukemia transcription factor 3 *ENSDARG0000001361578
pbx3a / pre-B-cell leukemia homeobox 3a / PBX3* / P40426* / O35317* / PBX homeobox 3* / Pre-B-cell leukemia transcription factor 3 *ENSDARG0000008926276
pbx2 / pre-B-cell leukemia homeobox 2 / O35984* / P40425* / PBX homeobox 2*ENSDARG0000001971771


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR005542  PBX
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001764 neuron migration IDA
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0003232 bulbus arteriosus development IMP
 biological_processGO:0003342 proepicardium development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0007411 axon guidance IDA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0030902 hindbrain development IGI
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031060 regulation of histone methylation IGI
 biological_processGO:0031061 negative regulation of histone methylation IGI
 biological_processGO:0035066 positive regulation of histone acetylation IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 biological_processGO:0048741 skeletal muscle fiber development IGI
 biological_processGO:0055007 cardiac muscle cell differentiation IGI
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005667 transcription factor complex IC
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation atrium anatomical region, abnormal
Show

 ZFA:0000008 brain brain quality , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle morphology , abnormal
cardiac ventricle cardiac muscle cell increased amount , abnormal
Show

 ZFA:0000017 endoderm endoderm morphology , abnormal
Show

 ZFA:0000029 hindbrain hindbrain quality , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary malformed , abnormal
Show

 ZFA:0000045 neural crest neural crest quality , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000076 swim bladder swim bladder physical object quality , abnormal
Show

 ZFA:0000084 yolk yolk quality , abnormal
Show

 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000121 lateral plate mesoderm lateral plate mesoderm increased distribution , abnormal
Show

 ZFA:0000123 liver liver mislocalised anteriorly , abnormal
Show

 ZFA:0000141 pectoral fin bud pectoral fin bud aplastic , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus smooth muscle spatial pattern , abnormal
Show

 ZFA:0000292 surface structure surface structure quality , abnormal
Show

 ZFA:0000360 heart tube heart tube increased distribution , abnormal
heart tube decreased amount , abnormal
Show

 ZFA:0000445 optic tectum optic tectum decreased size , abnormal
Show

 ZFA:0000471 atrium atrium cardiac muscle cell increased amount , abnormal
Show

 ZFA:0001032 rhombomere 4 rhombomere 4 RoL2 mislocalised , abnormal
Show

 ZFA:0001078 thymus thymus aplastic , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin aplastic , abnormal
pectoral fin quality , abnormal
pectoral fin absent , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Meckels cartilage fused with ceratohyal cartilage , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas mislocalised anteriorly , abnormal
Show

 ZFA:0001260 endocrine pancreas endocrine pancreas mislocalised anteriorly , abnormal
Show

 ZFA:0001319 myocardium myocardium decreased amount , abnormal
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 ZFA:0001383 fin bud fin bud aplastic , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage decreased size , abnormal
palatoquadrate cartilage fused with hyosymplectic cartilage , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage decreased size , abnormal
Show

 ZFA:0001422 hyosymplectic cartilage hyosymplectic cartilage decreased size , abnormal
Show

 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
Show

 ZFA:0005041 anterior lateral plate mesoderm anterior lateral plate mesoderm decreased amount , abnormal
anterior lateral plate mesoderm cardiac muscle cell decreased amount , abnormal
Show

 ZFA:0005198 RoL2 RoL2 increased amount , abnormal
Show

 ZFA:0005808 proepicardial cluster proepicardial cluster absent , abnormal
Show

 ZFA:0009003 cranial neural crest cell cranial neural crest cell mislocalised , abnormal
Show

 ZFA:0009149 Mauthner neuron Mauthner neuron absent , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased amount , abnormal
cardiac muscle cell increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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