ENSDARG00000052482


Danio rerio

Features
Gene ID: ENSDARG00000052482
  
Biological name :arhgef11
  
Synonyms : arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11
  
Possible biological names infered from orthology : O15085 / Rho guanine nucleotide exchange factor 11
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 5380320
Gene end: 5487593
  
Corresponding Affymetrix probe sets: Dr.26255.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000118588
Ensembl peptide - ENSDARP00000142086
Ensembl peptide - ENSDARP00000142240
swissprot - A0A140LFR2
swissprot - A0A140LG62
swissprot - B0S635
ZFIN ID - ZDB-GENE-070604-1
Ensembl - ENSDARG00000052482
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGEF11ENSGALG00000039163Gallus gallus
 O15085ENSG00000132694Homo sapiens
 Arhgef11ENSMUSG00000041977Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b / Q8R4H2* / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12* / Mus musculus Rho guanine nucleotide exchange fact...ENSDARG0000010091326
arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*ENSDARG0000003053225
arhgef1b / Rho guanine nucleotide exchange factor (GEF) 1b / Q61210* / Q92888* / ARHGEF1* / Rho guanine nucleotide exchange factor 1*ENSDARG0000005583723
si:dkey-172h23.2 / E9Q394* / AKAP13* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000002386816
arhgef1a / Rho guanine nucleotide exchange factor (GEF) 1a / Q92974* / Q60875* / ARHGEF2* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000004038016
arhgef28 / Rho guanine nucleotide exchange factor (GEF) 28 / Q8N1W1* / Rho guanine nucleotide exchange factor 28*ENSDARG0000006041516
AKAP13 / si:dkey-187e18.1 / E9Q394* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000007999416
arhgef18a / rho/rac guanine nucleotide exchange factor (GEF) 18a / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG0000001115715
arhgef18b / rho/rac guanine nucleotide exchange factor (GEF) 18b / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG0000004230814
arhgef2 / rho/rac guanine nucleotide exchange factor (GEF) 2 / Q92974* / Q60875* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000007581913
si:ch211-272b8.6 / Q8N1W1* / ARHGEF28* / Rho guanine nucleotide exchange factor 28*ENSDARG0000009160713
net1 / neuroepithelial cell transforming 1 / Q7Z628* / Q9Z206* / neuroepithelial cell transforming gene 1*ENSDARG0000003276511
arhgef3 / Rho guanine nucleotide exchange factor (GEF) 3 / Q91X46* / Q9NR81* / Rho guanine nucleotide exchange factor 3*ENSDARG0000001383410
arhgef3l / Rho guanine nucleotide exchange factor (GEF) 3, likeENSDARG0000003755410
si:dkey-91i10.2ENSDARG0000007403410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015212  Regulator of G protein signalling-like domain
 IPR016137  RGS domain
 IPR032919  Rho guanine nucleotide exchange factor 11


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003351 epithelial cilium movement IMP
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043149 stress fiber assembly IDA
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IPI
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle cilium decreased length , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000114 heart heart mislocalised , abnormal
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 ZFA:0000140 pancreas pancreas mislocalised , abnormal
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 ZFA:0000150 pronephric duct pronephric duct distended , abnormal
pronephric duct actin cytoskeleton disorganized , abnormal
pronephric duct cilium increased behavioural activity , abnormal
pronephric duct cystic , abnormal
pronephric duct sodium:potassium-exchanging ATPase complex mislocalised , abnormal
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 ZFA:0000151 pronephros pronephros distended , abnormal
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 ZFA:0000559 otolith organ otolith organ increased amount , abnormal
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 ZFA:0000944 posterior lateral line posterior lateral line neuromast hair cell positional polarity , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism lethal (sensu genetics) , abnormal
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 ZFA:0001115 trunk trunk curved ventral , abnormal
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 ZFA:0001261 ventricular system ventricular system increased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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