ENSDARG00000052696


Danio rerio

Features
Gene ID: ENSDARG00000052696
  
Biological name :bdh2
  
Synonyms : 3-hydroxybutyrate dehydrogenase, type 2 / bdh2 / Q561X9
  
Possible biological names infered from orthology : 3-hydroxybutyrate dehydrogenase 2 / Q8JZV9 / Q9BUT1
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 43714149
Gene end: 43727576
  
Corresponding Affymetrix probe sets: Dr.15584.1.S1_at (Zebrafish Array)   NM_001017809_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000146933
Ensembl peptide - ENSDARP00000069085
Ensembl peptide - ENSDARP00000117736
Ensembl peptide - ENSDARP00000119021
NCBI entrez gene - 550507     See in Manteia.
RefSeq - NM_001017809
RefSeq - XM_005160067
RefSeq Peptide - NP_001017809
swissprot - Q561X9
swissprot - Z4YIQ5
swissprot - B2GSA5
ZFIN ID - ZDB-GENE-050417-343
Ensembl - ENSDARG00000052696
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BDH2ENSGALG00000012338Gallus gallus
 BDH2ENSG00000164039Homo sapiens
 Bdh2ENSMUSG00000028167Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
zgc:113054ENSDARG0000005348335
hsd17b8 / hydroxysteroid (17-beta) dehydrogenase 8 / H2-Ke6* / P50171* / Q92506* / H2-K region expressed gene 6*ENSDARG0000000116931
zgc:101858ENSDARG0000003512931
dhrs4 / dehydrogenase/reductase (SDR family) member 4 / DHRS2* / Q13268* / Q99LB2* / Q6PKH6* / Q9BTZ2* / DHRS4L2* / dehydrogenase/reductase 2* / dehydrogenase/reductase 4* / dehydrogenase/r...ENSDARG0000002113529
hpgd / 15-hydroxyprostaglandin dehydrogenase / P15428* / Q8VCC1* / 15-hydroxyprostaglandin dehydrogenase [NAD(+)] *ENSDARG0000001201627
hsd17b10 / hydroxysteroid (17-beta) dehydrogenase 10 / Q99714*ENSDARG0000001778127
hsd17b14 / hydroxysteroid (17-beta) dehydrogenase 14 / Q9BPX1*ENSDARG0000005484227
dcxr / dicarbonyl/L-xylulose reductase / Cbr2* / Q91X52* / P08074* / Q7Z4W1* / L-xylulose reductase * / Carbonyl reductase [NADPH] 2 * / dicarbonyl and L-xylulose reductase*ENSDARG0000007927127
cbr4 / carbonyl reductase 4 / Q8N4T8* / Q91VT4* / Carbonyl reductase family member 4 *ENSDARG0000000907426
zgc:56585ENSDARG0000002623626


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR016040  NAD(P)-binding domain
 IPR020904  Short-chain dehydrogenase/reductase, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019290 siderophore biosynthetic process ISS
 biological_processGO:0042168 heme metabolic process IMP
 biological_processGO:0042541 hemoglobin biosynthetic process IMP
 biological_processGO:0043249 erythrocyte maturation IMP
 biological_processGO:0055072 iron ion homeostasis ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003858 3-hydroxybutyrate dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor ISS


Pathways (from Reactome)
Pathway description
Synthesis of Ketone Bodies


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0005237 erythroblast erythroblast nucleus increased size , abnormal
erythroblast mitophagy premature , abnormal
erythroblast mitophagy increased occurrence , abnormal
erythroblast nucleus size , ameliorated
erythroblast mitochondrion decreased amount , abnormal
erythroblast lysosome has extra parts of type erythroblast mitochondrion, abnormal
erythroblast mitophagy occurrence , ameliorated
erythroblast mitochondrion amount , ameliorated
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte hemoglobin complex decreased amount , abnormal
nucleate erythrocyte increased amount , abnormal
nucleate erythrocyte hemoglobin biosynthetic process occurrence , ameliorated
nucleate erythrocyte hemoglobin biosynthetic process decreased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000052696 bdh2 / Q561X9 / 3-hydroxybutyrate dehydrogenase, type 2 / Q8JZV9* / Q9BUT1* / 3-hydroxybutyrate dehydrogenase 2*  / complex






 

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