ENSDARG00000052893


Danio rerio

Features
Gene ID: ENSDARG00000052893
  
Biological name :rx3
  
Synonyms : retinal homeobox gene 3 / rx3
  
Possible biological names infered from orthology : O35602 / Q9Y2V3 / RAX / retina and anterior neural fold homeobox / Retinal homeobox protein Rx
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 10756154
Gene end: 10759223
  
Corresponding Affymetrix probe sets: Dr.540.1.S1_at (Zebrafish Array)   NM_131227_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000069319
NCBI entrez gene - 30474     See in Manteia.
RefSeq - NM_131227
RefSeq Peptide - NP_571302
swissprot - A8E7H4
ZFIN ID - ZDB-GENE-990415-238
Ensembl - ENSDARG00000052893
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAXENSGALG00000033279Gallus gallus
 RAXENSG00000134438Homo sapiens
 RaxENSMUSG00000024518Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rx1 / retinal homeobox gene 1 / RAX2* / Q96IS3* / retina and anterior neural fold homeobox 2*ENSDARG0000007168448
rx2 / retinal homeobox gene 2 / RAX2* / Q96IS3* / retina and anterior neural fold homeobox 2*ENSDARG0000004032146
arxa / O42115 / aristaless related homeobox a / ARX* / Q96QS3* / O35085* / Homeobox protein ARX * / aristaless related homeobox*ENSDARG0000005801129
alx4b / ALX homeobox 4b / ALX4* / O35137* / Q9H161* / ALX homeobox 4* / Homeobox protein aristaless-like 4 *ENSDARG0000007444227
alx4a / ALX homeobox 4a / ALX4* / O35137* / Q9H161* / ALX homeobox 4* / Homeobox protein aristaless-like 4 *ENSDARG0000008833227
alx1 / Q1LVQ7 / ALX homeobox 1 / Q15699* / Q8C8B0* / ALX homeobox protein 1 *ENSDARG0000006282426
vsx2 / visual system homeobox 2ENSDARG0000000557425
arxb / aristaless related homeobox b / ARX* / Q96QS3* / aristaless related homeobox*ENSDARG0000010152325
drgx / dorsal root ganglia homeobox / A6NNA5* / Prrxl1* / Q8BYH0* / paired related homeobox protein-like 1*ENSDARG0000006932923
uncx / UNC homeobox / A6NJT0* / O08934*ENSDARG0000010297623
vsx1 / visual system homeobox 1 homolog, chx10-like / Q91V10* / Q9NZR4* / visual system homeobox 1*ENSDARG0000005629222
phox2a / paired-like homeobox 2a / O14813* / Q62066* / Paired mesoderm homeobox protein 2A *ENSDARG0000000740621
phox2bb / paired-like homeobox 2bb / Q99453* / O35690* / PHOX2B* / paired like homeobox 2b* / Paired mesoderm homeobox protein 2B *ENSDARG0000009102921
uncx4.1 / Unc4.1 homeobox (C. elegans) / UNCX* / A6NJT0* / O08934* / UNC homeobox*ENSDARG0000003776020
si:dkey-43p13.5ENSDARG0000010419918
phox2ba / paired-like homeobox 2baENSDARG0000007533016


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000032 hypothalamus hypothalamus anterior region absent , abnormal
hypothalamus increased amount , abnormal
hypothalamus apoptotic process increased occurrence , abnormal
hypothalamus spatial pattern , abnormal
hypothalamus absent , abnormal
hypothalamus decreased amount , abnormal
hypothalamus anterior region decreased amount , abnormal
hypothalamus cell proliferation decreased occurrence , abnormal
hypothalamus mitotic cell cycle process increased occurrence , abnormal
hypothalamus dopaminergic neuron decreased amount , abnormal
hypothalamus spatial pattern , ameliorated
hypothalamus amount , ameliorated
hypothalamus mitotic cell cycle process occurrence , ameliorated
Show

 ZFA:0000035 lens lens quality , abnormal
Show

 ZFA:0000046 retinal neural layer retinal neural layer quality , abnormal
Show

 ZFA:0000079 telencephalon telencephalon mislocalised , abnormal
Show

 ZFA:0000107 eye eye aplastic , abnormal
eye absent , abnormal
eye quality , abnormal
Show

 ZFA:0000109 forebrain forebrain quality , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium quality , abnormal
Show

 ZFA:0000152 retina retina decreased size , abnormal
Show

 ZFA:0000161 third ventricle third ventricle anatomical region absent , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0000570 optic primordium optic primordium malformed , abnormal
Show

 ZFA:0000634 caudal hypothalamic zone caudal hypothalamic zone absent , abnormal
caudal hypothalamic zone anterior region absent , abnormal
caudal hypothalamic zone anterior region mislocalised , abnormal
Show

 ZFA:0001282 adenohypophysis adenohypophysis decreased amount , abnormal
Show

 ZFA:0001405 ethmoid cartilage ethmoid cartilage decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr