ENSDARG00000062824


Danio rerio

Features
Gene ID: ENSDARG00000062824
  
Biological name :alx1
  
Synonyms : alx1 / ALX homeobox 1 / Q1LVQ7
  
Possible biological names infered from orthology : ALX homeobox protein 1 / Q15699 / Q8C8B0
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 16246806
Gene end: 16254746
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000123391
swissprot - Q1LVQ7
ZFIN ID - ZDB-GENE-050419-191
Ensembl - ENSDARG00000062824
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ALX1ENSGALG00000027213Gallus gallus
 ALX1ENSG00000180318Homo sapiens
 Alx1ENSMUSG00000036602Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
alx4b / ALX homeobox 4b / ALX4* / O35137* / Q9H161* / ALX homeobox 4* / Homeobox protein aristaless-like 4 *ENSDARG0000007444238
alx4a / ALX homeobox 4a / ALX4* / O35137* / Q9H161* / ALX homeobox 4* / Homeobox protein aristaless-like 4 *ENSDARG0000008833237
arxa / O42115 / aristaless related homeobox a / ARX* / Q96QS3* / O35085* / Homeobox protein ARX * / aristaless related homeobox*ENSDARG0000005801128
arxb / aristaless related homeobox b / ARX* / Q96QS3* / aristaless related homeobox*ENSDARG0000010152325
rx3 / retinal homeobox gene 3 / RAX* / Q9Y2V3* / O35602* / Retinal homeobox protein Rx * / retina and anterior neural fold homeobox*ENSDARG0000005289324
vsx2 / visual system homeobox 2ENSDARG0000000557423
drgx / dorsal root ganglia homeobox / A6NNA5* / Prrxl1* / Q8BYH0* / paired related homeobox protein-like 1*ENSDARG0000006932923
rx1 / retinal homeobox gene 1 / RAX2* / Q96IS3* / retina and anterior neural fold homeobox 2*ENSDARG0000007168423
rx2 / retinal homeobox gene 2 / RAX2* / Q96IS3* / retina and anterior neural fold homeobox 2*ENSDARG0000004032122
phox2bb / paired-like homeobox 2bb / Q99453* / O35690* / PHOX2B* / paired like homeobox 2b* / Paired mesoderm homeobox protein 2B *ENSDARG0000009102921
uncx / UNC homeobox / A6NJT0* / O08934*ENSDARG0000010297621
phox2a / paired-like homeobox 2a / O14813* / Q62066* / Paired mesoderm homeobox protein 2A *ENSDARG0000000740620
uncx4.1 / Unc4.1 homeobox (C. elegans) / UNCX* / A6NJT0* / O08934* / UNC homeobox*ENSDARG0000003776020
vsx1 / visual system homeobox 1 homolog, chx10-like / Q91V10* / Q9NZR4* / visual system homeobox 1*ENSDARG0000005629219
si:dkey-43p13.5ENSDARG0000010419917
phox2ba / paired-like homeobox 2baENSDARG0000007533016


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR033209  ALX homeobox protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IMP
 cellular_componentGO:0005634 nucleus ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000035 lens lens decreased size , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer disorganized , abnormal
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 ZFA:0000640 cornea cornea disorganized , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001194 cranial neural crest cranial neural crest physical object quality , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage absent , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton absent , abnormal
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 ZFA:0001321 neurocranial trabecula neurocranial trabecula decreased size , abnormal
neurocranial trabecula absent , abnormal
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 ZFA:0001399 palatoquadrate cartilage palatoquadrate cartilage absent , abnormal
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 ZFA:0001405 ethmoid cartilage ethmoid cartilage decreased size , abnormal
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 ZFA:0001516 ceratobranchial cartilage ceratobranchial cartilage absent , abnormal
Show

 ZFA:0009003 cranial neural crest cell cranial neural crest cell mislocalised , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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