ENSMUSG00000036602


Mus musculus

Features
Gene ID: ENSMUSG00000036602
  
Biological name :Alx1
  
Synonyms : Alx1 / ALX homeobox protein 1 / Q8C8B0
  
Possible biological names infered from orthology : ALX homeobox 1 / Q15699
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D1
Gene start: 102998707
Gene end: 103030215
  
Corresponding Affymetrix probe sets: 10372145 (MoGene1.0st)   1435022_at (Mouse Genome 430 2.0 Array)   1456454_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151776
Ensembl peptide - ENSMUSP00000152018
Ensembl peptide - ENSMUSP00000152017
Ensembl peptide - ENSMUSP00000042512
Ensembl peptide - ENSMUSP00000129230
Ensembl peptide - ENSMUSP00000151728
NCBI entrez gene - 216285     See in Manteia.
MGI - MGI:104621
RefSeq - NM_172553
RefSeq - XM_006513529
RefSeq Peptide - NP_766141
swissprot - A0A1W2P8B9
swissprot - Q8C8B0
swissprot - A0A1W2P7M4
Ensembl - ENSMUSG00000036602
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alx1ENSDARG00000062824Danio rerio
 ALX1ENSGALG00000027213Gallus gallus
 ALX1ENSG00000180318Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Alx4 / O35137 / Homeobox protein aristaless-like 4 / Q9H161* / ALX homeobox 4*ENSMUSG0000004031040
Alx3 / O70137 / Homeobox protein aristaless-like 3 / O95076* / ALX homeobox 3*ENSMUSG0000001460339
Arx / O35085 / Homeobox protein ARX / Q96QS3* / aristaless related homeobox*ENSMUSG0000003527730
Phox2a / Q62066 / Paired mesoderm homeobox protein 2A / O14813* / paired like homeobox 2a*ENSMUSG0000000794624
Rax / O35602 / Retinal homeobox protein Rx / Q9Y2V3* / retina and anterior neural fold homeobox*ENSMUSG0000002451824
Vsx2 / Q61412 / visual system homeobox 2 / P58304*ENSMUSG0000002123923
Uncx / O08934 / UNC homeobox / A6NJT0*ENSMUSG0000002954623
Prrxl1 / Q8BYH0 / paired related homeobox protein-like 1 / DRGX* / A6NNA5* / dorsal root ganglia homeobox*ENSMUSG0000004173022
O35690 / Phox2b / Paired mesoderm homeobox protein 2B / Q99453* / paired like homeobox 2b*ENSMUSG0000001252021
Vsx1 / Q91V10 / visual system homeobox 1 / Q9NZR4*ENSMUSG0000003308021
Isx / A1A546 / intestine specific homeobox / Q2M1V0*ENSMUSG0000003162119


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003654  OAR domain
 IPR009057  Homeobox-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR033209  ALX homeobox protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0014031 mesenchymal cell development IMP
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048704 embryonic skeletal system morphogenesis IGI
 biological_processGO:0060021 roof of mouth development IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016604 nuclear body ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000075 absent neurocranium "missing bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000106 abnormal basisphenoid bone morphology "malformed base of the sphenoid bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
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Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Trigq3C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4lst-J/Alx4lst-J,Tbx15de-H/Tbx15+
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6J

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx3tm1Hubr/Alx3tm1Hubr
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd

 MP:0000155 asymmetric rib attachment "loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum" [J:19212]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000757 herniated abdominal wall "protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002778 meroanencephaly "type of anencephaly in which the brain and cranium are present in rudimentary form" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator, J:33716]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003104 acrania "complete or partial absence of a skull; usually associated with anencephaly" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:33716]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003108 short zygomatic bone "reduced length of the bone that forms the prominence of the cheek" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004320 split sternum "the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004339 absent clavicle "missing one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tbx15de-H/Tbx15de-H
Genetic Background: B6EiC3 a/A-Tbx15de-H/J

 MP:0004342 scapular bone foramen "presence of a hole in either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4lst-J/Alx4lst-J,Tbx15de-H/Tbx15de-H
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6J

 MP:0004343 small scapula "reduced size of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx15de-H/Tbx15de-H
Genetic Background: B6EiC3 a/A-Tbx15de-H/J

 MP:0004345 abnormal acromion morphology "any structural anomaly of the lateral end of the spine of the scapula which projects as a broad flattened process and articulates with the clavicle, and forms the point of the shoulder" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J

 MP:0004347 abnormal scapular spine morphology "any structural anomaly of the trianguar ridge on the dorsal aspect of the scapula which separates the supra- from the infraspinatous fossa and where the trapezius and deltoid muscles are attached " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4lst-J/Alx4lst-J,Tbx15de-H/Tbx15+
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6J

 MP:0004377 small frontal bone "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004383 absent interparietal bone "absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004418 small parietal bone "reduced size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004422 small temporal bone "reduced size of the large, irregular bone located at the base and side of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004441 small occipital bone "reduced size of the bone at the lower, posterior part of the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004444 small supraoccipital bone "reduced size of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004449 absent presphenoid bone "absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004459 small alisphenoid bone "reduced size of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004508 abnormal shoulder bone morphology "any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Trigq3C3H/HeJ/?
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004692 small pubic bone "reduced size of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J

 MP:0004726 abnormal nasal capsule morphology "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005249 abnormal palatine bone morphology "structural anomaly of the anteriorly located rigid section of the palate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4lst-J/Alx4lst-J
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C57BL/6J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011862 decreased cranium length "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0012702 increased embryonic neuroepithelium thickness "increased width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0030066 short face "an abnormally decreased height (length) of the face" [MGI:anna]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0030121 small temporal bone squamous part "reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna]
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0030200 abnormal nasal septum cartilage morphology "any structural anomaly of the hyaline cartilage of the nasal septum that is somewhat quadrilateral in shape, thicker at its margins than at its center, and completes the separation between the nasal cavities" [https://en.wikipedia.org/wiki/Septal_nasal_cartilage, MGI:anna]
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Allelic Composition: Alx1tm1Crm/Alx1+,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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