ENSDARG00000053586


Danio rerio
crebcreb1aactivationbindingtranscriptionnucleuscampresponseelementproteincoactivatorcbppkidbasic-leucinezipperdomainsomitogenesisregulationdna-templatedmidbrain-hindbrainboundarydevelopmentconvergentextensioninvolvedaxiselongationdnadna-bindingfactor

Features
Gene ID: ENSDARG00000053586
  
Biological name :creb1a
  
Synonyms : cAMP responsive element binding protein 1a / creb1a
  
Possible biological names infered from orthology : cAMP responsive element binding protein 1 / CREB1 / Cyclic AMP-responsive element-binding protein 1 / P16220 / Q01147
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 33547532
Gene end: 33557915
  
Corresponding Affymetrix probe sets: Dr.19426.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000070114
Ensembl peptide - ENSDARP00000151743
NCBI entrez gene - 573207     See in Manteia.
RefSeq - NM_200909
RefSeq Peptide - NP_957203
swissprot - Q803K8
ZFIN ID - ZDB-GENE-040426-750
Ensembl - ENSDARG00000053586
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CREB1ENSGALG00000008494Gallus gallus
 CREB1ENSG00000118260Homo sapiens
 Creb1ENSMUSG00000025958Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
creb1b / cAMP responsive element binding protein 1b / CREB1* / P16220* / Q01147* / cAMP responsive element binding protein 1* / Cyclic AMP-responsive element-binding protein 1 *ENSDARG0000009342092
atf1 / activating transcription factor 1 / P18846* / P81269* / Cyclic AMP-dependent transcription factor ATF-1 *ENSDARG0000004430157
crema / cAMP responsive element modulator a / CREM* / P27699* / Q03060* / cAMP responsive element modulator*ENSDARG0000002321725
cremb / cAMP responsive element modulator bENSDARG0000010289921


Protein motifs (from Interpro)
Interpro ID Name
 IPR001630  cAMP response element binding (CREB) protein
 IPR003102  Coactivator CBP, pKID
 IPR004827  Basic-leucine zipper domain


Gene Ontology (GO)
anatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthanatomical structure developmentnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processdevelopmental growthanatomical structureanatomical structure developmentnitrogen compound menitrogen compound metabolic processbiosynthetic processbiosynthetic processcellular metabolic pcellular metabolic processprimary metabolic prprimary metabolic processorganic substance meorganic substance metabolic processdevelopmental growthdevelopmental growth
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityDNA-binding transcription factor activity
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030917 midbrain-hindbrain boundary development IMP
 biological_processGO:0060028 convergent extension involved in axis elongation IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
AKT phosphorylates targets in the nucleus
CREB phosphorylation
NCAM signaling for neurite out-growth
CREB phosphorylation through the activation of CaMKK
CREB phosphorylation through the activation of Adenylate Cyclase
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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