ENSG00000118260


Homo sapiens
bindingCREB1regulationtranscriptionresponsefactorrnapolymeraseiiproteingrowthcellularcrebphosphorylationdnaactivitystimulussequence-specificprocessdevelopmentactivationsignalingcelldifferentiationtranscriptionaldomaindna-templatedtransformingbetacircadianpromoter

Features
Gene ID: ENSG00000118260
  
Biological name :CREB1
  
Synonyms : cAMP responsive element binding protein 1 / CREB1 / P16220
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q33.3
Gene start: 207529737
Gene end: 207603431
  
Corresponding Affymetrix probe sets: 204312_x_at (Human Genome U133 Plus 2.0 Array)   204313_s_at (Human Genome U133 Plus 2.0 Array)   204314_s_at (Human Genome U133 Plus 2.0 Array)   214513_s_at (Human Genome U133 Plus 2.0 Array)   225565_at (Human Genome U133 Plus 2.0 Array)   225572_at (Human Genome U133 Plus 2.0 Array)   237289_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401803
Ensembl peptide - ENSP00000392428
Ensembl peptide - ENSP00000403678
Ensembl peptide - ENSP00000412016
Ensembl peptide - ENSP00000407227
Ensembl peptide - ENSP00000405711
Ensembl peptide - ENSP00000405539
Ensembl peptide - ENSP00000404890
Ensembl peptide - ENSP00000236995
Ensembl peptide - ENSP00000387699
Ensembl peptide - ENSP00000391125
NCBI entrez gene - 1385     See in Manteia.
OMIM - 123810
RefSeq - XM_017003401
RefSeq - NM_001320793
RefSeq - NM_004379
RefSeq - NM_134442
RefSeq - XM_011510645
RefSeq - XM_011510646
RefSeq - XM_011510647
RefSeq - XM_011510648
RefSeq - XM_011510649
RefSeq - XM_011510650
RefSeq - XM_011510651
RefSeq - XM_017003399
RefSeq - XM_017003400
RefSeq Peptide - NP_604391
RefSeq Peptide - NP_001307722
RefSeq Peptide - NP_004370
swissprot - C9JCI4
swissprot - C9JBT4
swissprot - C9J896
swissprot - C9J4L5
swissprot - H7C1R5
swissprot - H7C3I0
swissprot - Q53X93
swissprot - Q5U0J5
swissprot - C9J276
swissprot - P16220
swissprot - E7EWP8
Ensembl - ENSG00000118260
  
Related genetic diseases (OMIM): 612160 - Histiocytoma, angiomatoid fibrous, somatic, 612160

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 creb1aENSDARG00000053586Danio rerio
 creb1bENSDARG00000093420Danio rerio
 CREB1ENSGALG00000008494Gallus gallus
 Creb1ENSMUSG00000025958Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CREM / Q03060 / cAMP responsive element modulatorENSG0000009579451
ATF1 / P18846 / activating transcription factor 1ENSG0000012326849


Protein motifs (from Interpro)
Interpro ID Name
 IPR001630  cAMP response element binding (CREB) protein
 IPR003102  Coactivator CBP, pKID
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029802  cAMP-responsive element-binding protein 1


Gene Ontology (GO)
response to stressresponse to abiotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processresponse to external stimulusmovement of cell or subcellular componentagingestablishment of localizationregulation of biological qualitysystem processcircadian rhythmresponse to activityinterspecies interaction between organismscytokine productiondevelopmental growthcell deathcellular component biogenesisfibroblast proliferationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processresponse to external stimulusmovement of cell or subcellular componentagingestablishment of localizationregulation of biological qualitysystem processcircadian rhythmresponse to activityinterspecies interaction between organismscytokine productiondevelopmental growthcell deathcellular component biogenesisfibroblast proliferationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processresponse to external stimulusmovement of cell or subcellular componentagingestablishment of localizationregulation of biological qualitysystem processcircadian rhythmresponse to activityinterspecies interaction between organismscytokine productiondevelopmental growthcell deathcellular component biogenesisfibroblast proliferationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processresponse to external stimulusmovement of cell or subcellular componentagingestablishment of localizationregulation of biological qualitysystem processcircadian rhythmresponse to activityinterspecies interaction between organismscytokine productiondevelopmental growthcell deathcellular component biogenesisfibroblast proliferationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processresponse to external stimulusmovement of cell or subcellular componentagingestablishment of localizationregulation of biological qualitysystem processcircadian rhythmresponse to activityinterspecies interaction between organismscytokine productiondevelopmental growthcell deathcellular component biogenesisfibroblast proliferationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processresponse to external stimulusmovement of cell or subcellular componentagingestablishment of localizationregulation of biological qualitysystem processcircadian rhythmresponse to activityinterspecies interaction between organismscytokine productiondevelopmental growthcell deathcellular component biogenesisfibroblast proliferationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processresponse to external stimulusmovement of cell or subcellular componentagingestablishment of localizationregulation of biological qualitysystem processcircadian rhythmresponse to activityinterspecies interaction between organismscytokine productiondevelopmental growthcell deathcellular component biogenesisfibroblast proliferationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processresponse to external stimulusmovement of cell or subcellular componentagingestablishment of localizationregulation of biological qualitysystem processcircadian rhythmresponse to activityinterspecies interaction between organismscytokine productiondevelopmental growthcell deathcellular component biogenesisfibroblast proliferationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processresponse to external stimulusmovement of cell or subcellular componentagingestablishment of localizationregulation of biological qualitysystem processcircadian rhythmresponse to activityinterspecies interaction between organismscytokine productiondevelopmental growthcell deathcellular component biogenesisfibroblast proliferationresponse to stressresponse to abiotic stimulusnitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcellular component organizationanatomical structure developmentcellular developmental processresponse to external stimulusmovement of cell or subcellular componentagingestablishment of localizationregulation of biological qualitysystem processcircadian rhythmresponse to activityinterspecies interaction between organismscytokine productiondevelopmental growthcell deathcellular component biogenesisfibroblast proliferationresporesponse to stressresporesponse to abiotic stimulusnitronitrogen compound metabolic processbiosybiosynthetic processcellucellular metabolic processprimaprimary metabolic processorganorganic substance metabolic processcell cell communicationcellucellular response to stimulusresporesponse to endogenous stimulusresporesponse to chemicalcellucellular component organizationanatoanatomical structure developmentcellucellular developmental processresporesponse to external stimulusmovemmovement of cell or subcellular componentagingagingestabestablishment of localizationregulregulation of biological qualitysystesystem processcircacircadian rhythmresporesponse to activityinterinterspecies interaction between organismscytokcytokine productiondeveldevelopmental growthcell cell deathcellucellular component biogenesisfibrofibroblast proliferation
organic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingtranscription factor activity, protein bindingtranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingtranscription factor activity, protein bindingtranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingtranscription factor activity, protein bindingtranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingtranscription factor activity, protein bindingtranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingtranscription factor activity, protein bindingtranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingtranscription factor activity, protein bindingtranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingtranscription factor activity, protein bindingtranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingtranscription factor activity, protein bindingtranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingtranscription factor activity, protein bindingtranscription coregulator activityorganic cyclic compound bindingheterocyclic compound bindingDNA-binding transcription factor activityprotein bindingtranscription factor activity, protein bindingtranscription coregulator activityorganic cyclic compoundorganic cyclic compound bindingheterocyclic compound bheterocyclic compound bindingDNA-binding transcriptiDNA-binding transcription factor activityprotein bindingprotein bindingtranscription factor actranscription factor activity, protein bindingtranscription coregulattranscription coregulator activity
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0007623 circadian rhythm ISS
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010944 negative regulation of transcription by competitive promoter binding IDA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030879 mammary gland development IEA
 biological_processGO:0032916 positive regulation of transforming growth factor beta3 production IEA
 biological_processGO:0033363 secretory granule organization IEA
 biological_processGO:0033762 response to glucagon ISS
 biological_processGO:0034670 chemotaxis to arachidonic acid IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling TAS
 biological_processGO:0045600 positive regulation of fat cell differentiation ISS
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046887 positive regulation of hormone secretion IEA
 biological_processGO:0046889 positive regulation of lipid biosynthetic process ISS
 biological_processGO:0048145 regulation of fibroblast proliferation IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0055025 positive regulation of cardiac muscle tissue development IEA
 biological_processGO:0060251 regulation of glial cell proliferation IEA
 biological_processGO:0060428 lung epithelium development IEA
 biological_processGO:0060430 lung saccule development IEA
 biological_processGO:0060509 type I pneumocyte differentiation IEA
 biological_processGO:0071294 cellular response to zinc ion IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1902065 response to L-glutamate IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990314 cellular response to insulin-like growth factor stimulus IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:1990589 ATF4-CREB1 transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0001225 RNA polymerase II transcription coactivator binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003712 transcription coregulator activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030544 Hsp70 protein binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0035497 cAMP response element binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:1990763 arrestin family protein binding IEA


Pathways (from Reactome)
Pathway description
PKA-mediated phosphorylation of CREB
CaMK IV-mediated phosphorylation of CREB
AKT phosphorylates targets in the nucleus
CREB phosphorylation
Transcriptional activation of mitochondrial biogenesis
NOTCH2 intracellular domain regulates transcription
NCAM signaling for neurite out-growth
Circadian Clock
CREB phosphorylation through the activation of CaMKK
CREB phosphorylation through the activation of Adenylate Cyclase
CREB phosphorylation through the activation of CaMKII
CREB phosphorylation through the activation of Ras
Constitutive Signaling by AKT1 E17K in Cancer
Gastrin-CREB signalling pathway via PKC and MAPK


Phenotype (from MGI, Zfin or HPO)
Somatic mutationNeoplasiaSomatic mutationNeoplasiaSomatic mutationNeoplasiaSomatic mutationNeoplasiaSomatic mutationNeoplasiaSomatic mutationNeoplasiaSomatic mutationNeoplasiaSomatic mutationNeoplasiaSomatic mutationNeoplasiaSomatic mutationNeoplasiaSomatic mutationSomatic mutationNeoplasiaNeoplasia
IDPhenotypeDefinition Genetic BG
 HP:0001428 Somatic mutation 
Show

 HP:0012315 Histiocytoma "A neoplasm containing histiocytes." [HPO:probinson]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134250 NOTCH2 / Q04721  / complex / reaction
 ENSG00000071242 Q15349 / RPS6KA2 / ribosomal protein S6 kinase A2  / reaction
 ENSG00000072133 Q9UK32 / RPS6KA6 / ribosomal protein S6 kinase A6  / reaction
 ENSG00000058404 CAMK2B / Q13554 / calcium/calmodulin dependent protein kinase II beta  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction
 ENSG00000160741 CRTC2 / Q53ET0 / CREB regulated transcription coactivator 2  / complex
 ENSG00000162889 P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2  / reaction
 ENSG00000148660 CAMK2G / Q13555 / calcium/calmodulin dependent protein kinase II gamma  / reaction
 ENSG00000152495 CAMK4 / Q16566 / calcium/calmodulin dependent protein kinase IV  / reaction
 ENSG00000161021 MAML1 / Q92585 / mastermind like transcriptional coactivator 1  / complex / reaction
 ENSG00000145349 CAMK2D / Q13557 / calcium/calmodulin dependent protein kinase II delta  / reaction
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / reaction
 ENSG00000140577 CRTC3 / Q6UUV7 / CREB regulated transcription coactivator 3  / complex
 ENSG00000168214 RBPJ / Q06330 / recombination signal binding protein for immunoglobulin kappa J region  / complex / reaction
 ENSG00000105662 CRTC1 / Q6UUV9 / CREB regulated transcription coactivator 1  / complex
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000070808 CAMK2A / Q9UQM7 / calcium/calmodulin dependent protein kinase II alpha  / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction
 ENSG00000169057 MECP2 / P51608 / methyl-CpG binding protein 2  / complex / reaction
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / complex / reaction
 ENSG00000196782 MAML3 / Q96JK9 / mastermind like transcriptional coactivator 3  / complex / reaction
 ENSG00000184384 MAML2 / Q8IZL2 / mastermind like transcriptional coactivator 2  / complex / reaction
 ENSG00000117676 Q15418 / RPS6KA1 / ribosomal protein S6 kinase A1  / reaction
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / reaction
 ENSG00000177189 P51812 / RPS6KA3 / ribosomal protein S6 kinase A3  / reaction
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / reaction
 ENSG00000100784 O75582 / RPS6KA5 / ribosomal protein S6 kinase A5  / reaction






 

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