ENSG00000165059


Homo sapiens

Features
Gene ID: ENSG00000165059
  
Biological name :PRKACG
  
Synonyms : P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q21.11
Gene start: 69012529
Gene end: 69014113
  
Corresponding Affymetrix probe sets: 207228_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366488
NCBI entrez gene - 5568     See in Manteia.
OMIM - 176893
RefSeq - NM_002732
RefSeq Peptide - NP_002723
swissprot - P22612
Ensembl - ENSG00000165059
  
Related genetic diseases (OMIM): 616176 - ?Bleeding disorder, platelet-type, 19, 616176
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alphaENSG0000007206284
P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit betaENSG0000014287577
PRKX / P51817 / protein kinase, X-linkedENSG0000018394344
PRKG2 / Q13237 / protein kinase, cGMP-dependent, type IIENSG0000013866941
PRKG1 / Q13976 / protein kinase, cGMP-dependent, type IENSG0000018553241


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0003091 renal water homeostasis TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0008584 male gonad development TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034199 activation of protein kinase A activity TAS
 biological_processGO:0034380 high-density lipoprotein particle assembly TAS
 biological_processGO:0071377 cellular response to glucagon stimulus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0045171 intercellular bridge IDA
 cellular_componentGO:0097546 ciliary base TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004691 cAMP-dependent protein kinase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
PKA-mediated phosphorylation of CREB
PKA-mediated phosphorylation of key metabolic factors
Triglyceride catabolism
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Rap1 signalling
Regulation of insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
VEGFA-VEGFR2 Pathway
CREB phosphorylation through the activation of Adenylate Cyclase
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog off state
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
Glycolysis
RET signaling
HDL assembly
ROBO receptors bind AKAP5
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000132 Menorrhagia 
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 HP:0000421 Epistaxis 
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 HP:0001903 Anemia 
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 HP:0007420 Spontaneous hematomas 
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 HP:0040185 Macrothrombocytopenia 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108599 AKAP10 / O43572 / A-kinase anchoring protein 10  / complex / reaction
 ENSG00000121057 AKAP1 / Q92667 / A-kinase anchoring protein 1  / complex / reaction
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / complex
 ENSG00000167580 AQP2 / P41181 / aquaporin 2  / reaction
 ENSG00000111087 GLI1 / P08151 / GLI family zinc finger 1  / reaction
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / reaction
 ENSG00000079435 LIPE / Q05469 / lipase E, hormone sensitive type  / reaction
 ENSG00000114302 P13861 / PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha  / complex
 ENSG00000005249 P31323 / PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit beta  / complex
 ENSG00000132359 Q684P5 / RAP1GAP2 / RAP1 GTPase activating protein 2  / reaction
 ENSG00000009950 MLXIPL / Q9NP71 / MLX interacting protein like  / reaction
 ENSG00000173039 RELA / Q04206 / RELA proto-oncogene, NF-kB subunit  / reaction
 ENSG00000166819 PLIN1 / O60240 / perilipin 1  / reaction
 ENSG00000140575 IQGAP1 / P46940 / IQ motif containing GTPase activating protein 1  / complex
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / complex
 ENSG00000184588 PDE4B / Q07343 / phosphodiesterase 4B  / reaction
 ENSG00000185008 ROBO2 / Q9HCK4 / roundabout guidance receptor 2  / complex / reaction
 ENSG00000074047 GLI2 / P10070 / GLI family zinc finger 2  / reaction
 ENSG00000179841 AKAP5 / P24588 / A-kinase anchoring protein 5  / complex / reaction
 ENSG00000188191 P31321 / PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta  / complex
 ENSG00000108946 P10644 / PRKAR1A / protein kinase cAMP-dependent type I regulatory subunit alpha  / complex
 ENSG00000118260 CREB1 / P16220 / cAMP responsive element binding protein 1  / reaction
 ENSG00000107882 SUFU / Q9UMX1 / SUFU negative regulator of hedgehog signaling  / reaction
 ENSG00000165029 ABCA1 / O95477 / ATP binding cassette subfamily A member 1  / reaction
 ENSG00000158571 P16118 / PFKFB1 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1  / reaction
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / complex
 ENSG00000106571 GLI3 / P10071 / GLI family zinc finger 3  / reaction
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / reaction






 

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