ENSG00000138669


Homo sapiens

Features
Gene ID: ENSG00000138669
  
Biological name :PRKG2
  
Synonyms : PRKG2 / protein kinase, cGMP-dependent, type II / Q13237
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q21.21
Gene start: 81087370
Gene end: 81215117
  
Corresponding Affymetrix probe sets: 207505_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000439967
Ensembl peptide - ENSP00000486129
Ensembl peptide - ENSP00000264399
Ensembl peptide - ENSP00000378945
NCBI entrez gene - 5593     See in Manteia.
OMIM - 601591
RefSeq - XM_017008417
RefSeq - NM_001282482
RefSeq - NM_001282483
RefSeq - NM_001282485
RefSeq - NM_006259
RefSeq - XM_005263126
RefSeq - XM_017008413
RefSeq - XM_017008414
RefSeq - XM_017008415
RefSeq - XM_017008416
RefSeq - NM_001282480
RefSeq - NM_001282481
RefSeq Peptide - NP_001269410
RefSeq Peptide - NP_001269411
RefSeq Peptide - NP_001269412
RefSeq Peptide - NP_001269414
RefSeq Peptide - NP_006250
RefSeq Peptide - NP_001269409
swissprot - A0A140VJM3
swissprot - B7ZA25
swissprot - Q13237
Ensembl - ENSG00000138669
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkg2ENSDARG00000054741Danio rerio
 PRKG2ENSGALG00000010909Gallus gallus
 Prkg2ENSMUSG00000029334Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKG1 / Q13976 / protein kinase, cGMP-dependent, type IENSG0000018553246
P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit betaENSG0000014287521
P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alphaENSG0000007206220
P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gammaENSG0000016505919
PRKX / P51817 / protein kinase, X-linkedENSG0000018394319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002374  cGMP-dependent kinase
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014710  RmlC-like jelly roll fold
 IPR017441  Protein kinase, ATP binding site
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR035014  cGMP-dependent protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IEA
 biological_processGO:0051186 cofactor metabolic process TAS
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:2001226 negative regulation of chloride transport IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004692 cGMP-dependent protein kinase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030553 cGMP binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Ca2+ pathway
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116096 SPR / P35270 / sepiapterin reductase  / reaction
 ENSG00000138669 PRKG2 / Q13237 / protein kinase, cGMP-dependent, type II  / complex
 ENSG00000135643 KCNMB4 / Q86W47 / potassium calcium-activated channel subfamily M regulatory beta subunit 4  / reaction
 ENSG00000156113 KCNMA1 / Q12791 / potassium calcium-activated channel subfamily M alpha 1  / reaction
 ENSG00000145936 KCNMB1 / Q16558 / potassium calcium-activated channel subfamily M regulatory beta subunit 1  / reaction
 ENSG00000150787 PTS / Q03393 / 6-pyruvoyltetrahydropterin synthase  / reaction
 ENSG00000150995 ITPR1 / Q14643 / inositol 1,4,5-trisphosphate receptor type 1  / reaction
 ENSG00000171121 KCNMB3 / Q9NPA1 / potassium calcium-activated channel subfamily M regulatory beta subunit 3  / reaction
 ENSG00000197584 KCNMB2 / Q9Y691 / potassium calcium-activated channel subfamily M regulatory beta subunit 2  / reaction
 ENSG00000072952 MRVI1 / Q9Y6F6 / murine retrovirus integration site 1 homolog  / reaction






 

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