ENSG00000197584


Homo sapiens

Features
Gene ID: ENSG00000197584
  
Biological name :KCNMB2
  
Synonyms : KCNMB2 / potassium calcium-activated channel subfamily M regulatory beta subunit 2 / Q9Y691
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q26.32
Gene start: 178272932
Gene end: 178844429
  
Corresponding Affymetrix probe sets: 221097_s_at (Human Genome U133 Plus 2.0 Array)   223823_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399100
Ensembl peptide - ENSP00000484788
Ensembl peptide - ENSP00000414228
Ensembl peptide - ENSP00000408252
Ensembl peptide - ENSP00000407592
Ensembl peptide - ENSP00000351068
Ensembl peptide - ENSP00000395807
Ensembl peptide - ENSP00000397483
NCBI entrez gene - 10242     See in Manteia.
OMIM - 605214
RefSeq - XM_011512325
RefSeq - NM_001278911
RefSeq - NM_005832
RefSeq - NM_181361
RefSeq Peptide - NP_852006
RefSeq Peptide - NP_001265840
RefSeq Peptide - NP_005823
swissprot - E7EM81
swissprot - F8WE19
swissprot - B5BNW5
swissprot - Q9Y691
swissprot - E7ETM2
Ensembl - ENSG00000197584
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnmb2ENSDARG00000006568Danio rerio
 si:ch211-247n2.1ENSDARG00000001712Danio rerio
 ENSGALG00000031929Gallus gallus
 Kcnmb2ENSMUSG00000037610Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC117457.1ENSG00000275163100
KCNMB3 / Q9NPA1 / potassium calcium-activated channel subfamily M regulatory beta subunit 3ENSG0000017112139
KCNMB1 / Q16558 / potassium calcium-activated channel subfamily M regulatory beta subunit 1ENSG0000014593635
KCNMB4 / Q86W47 / potassium calcium-activated channel subfamily M regulatory beta subunit 4ENSG0000013564326


Protein motifs (from Interpro)
Interpro ID Name
 IPR003930  Potassium channel, calcium-activated, BK, beta subunit
 IPR015382  KCNMB2, ball/chain domain
 IPR037096  KCNMB2, ball/chain domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001508 action potential IDA
 biological_processGO:0005513 detection of calcium ion IDA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0019228 neuronal action potential IDA
 biological_processGO:0019229 regulation of vasoconstriction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008200 ion channel inhibitor activity TAS
 molecular_functionGO:0015269 calcium-activated potassium channel activity IEA
 molecular_functionGO:0015459 potassium channel regulator activity TAS


Pathways (from Reactome)
Pathway description
Ca2+ activated K+ channels
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138669 PRKG2 / Q13237 / protein kinase, cGMP-dependent, type II  / reaction
 ENSG00000135643 KCNMB4 / Q86W47 / potassium calcium-activated channel subfamily M regulatory beta subunit 4  / complex
 ENSG00000156113 KCNMA1 / Q12791 / potassium calcium-activated channel subfamily M alpha 1  / complex
 ENSG00000145936 KCNMB1 / Q16558 / potassium calcium-activated channel subfamily M regulatory beta subunit 1  / complex
 ENSG00000171121 KCNMB3 / Q9NPA1 / potassium calcium-activated channel subfamily M regulatory beta subunit 3  / complex
 ENSG00000197584 KCNMB2 / Q9Y691 / potassium calcium-activated channel subfamily M regulatory beta subunit 2  / complex
 ENSG00000185532 PRKG1 / Q13976 / protein kinase, cGMP-dependent, type I  / reaction






 

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