Manteia

ENSMUSG00000037610

Mus musculus

Features

Gene ID:	ENSMUSG00000037610

Biological name :	Kcnmb2

Synonyms :	Calcium-activated potassium channel subunit beta-2 / Kcnmb2 / Q9CZM9

Possible biological names infered from orthology :	AC117457.1 / potassium calcium-activated channel subfamily M regulatory beta subunit 2 / Q9Y691

Species:	Mus musculus

Chr. number:	3
Strand:	1
Band:	A3
Gene start:	31902507
Gene end:	32200180

Corresponding Affymetrix probe sets:	10491319 (MoGene1.0st) 1426322_a_at (Mouse Genome 430 2.0 Array) 1431844_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000112531 Ensembl peptide - ENSMUSP00000141656 Ensembl peptide - ENSMUSP00000141955 Ensembl peptide - ENSMUSP00000141858 Ensembl peptide - ENSMUSP00000113234 Ensembl peptide - ENSMUSP00000136596 NCBI entrez gene - 72413 See in Manteia. MGI - MGI:1919663 RefSeq - XM_017319742 RefSeq - XM_006535548 RefSeq - XM_006535549 RefSeq - XM_006535550 RefSeq - XM_006535551 RefSeq - NM_028231 RefSeq Peptide - NP_082507 swissprot - A0A0A6YXE4 swissprot - B5BNW2 swissprot - Q9CZM9 Ensembl - ENSMUSG00000037610

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kcnmb1 / potassium calcium-activated channel subfamily M regulatory beta subunit 1 / Q16558*	ENSMUSG00000020155	35
Kcnmb3 / potassium calcium-activated channel subfamily M regulatory beta subunit 3 / Q9NPA1*	ENSMUSG00000091091	35
Kcnmb4 / Q9JIN6 / Calcium-activated potassium channel subunit beta-4 / Q86W47* / potassium calcium-activated channel subfamily M regulatory beta subunit 4*	ENSMUSG00000054934	26

Protein motifs (from Interpro)

Interpro ID	Name
IPR003930	Potassium channel, calcium-activated, BK, beta subunit
IPR015382	KCNMB2, ball/chain domain
IPR037096	KCNMB2, ball/chain domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001508	action potential	ISO
biological_process	GO:0005513	detection of calcium ion	IBA
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006813	potassium ion transport	ISO
biological_process	GO:0007268	chemical synaptic transmission	IBA
biological_process	GO:0019228	neuronal action potential	ISO
biological_process	GO:0065009	regulation of molecular function	IEA
biological_process	GO:0071805	potassium ion transmembrane transport	IBA
cellular_component	GO:0005887	integral component of plasma membrane	ISO
cellular_component	GO:0008076	voltage-gated potassium channel complex	IBA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0015269	calcium-activated potassium channel activity	IBA
molecular_function	GO:0015459	potassium channel regulator activity	IBA

Pathways (from Reactome)

Pathway description

Ca2+ activated K+ channels

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcc6^tm1Jfk/Abcc6^tm1Jfk,Samd9l^tm1Homy/Samd9l^tm1Homy Genetic Background: B6.129-Samd9l^tm1Homy Abcc6^tm1Jfk
MP:0002578	impaired ability to fire action potentials	"anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcc6^tm1Jfk/Abcc6^tm1Jfk,Samd9l^tm1Homy/Samd9l^tm1Homy Genetic Background: B6.129-Samd9l^tm1Homy Abcc6^tm1Jfk
MP:0003484	abnormal channel response	"anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]	Show Allelic Composition: Abcc6^tm1Jfk/Abcc6^tm1Jfk,Samd9l^tm1Homy/Samd9l^tm1Homy Genetic Background: B6.129-Samd9l^tm1Homy Abcc6^tm1Jfk
MP:0005402	abnormal action potential	"change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Abcc6^tm1Jfk/Abcc6^tm1Jfk,Samd9l^tm1Homy/Samd9l^tm1Homy Genetic Background: B6.129-Samd9l^tm1Homy Abcc6^tm1Jfk

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020155	Kcnmb1 / potassium calcium-activated channel subfamily M regulatory beta subunit 1 / Q16558*	/ complex
ENSMUSG00000054934	Kcnmb4 / Q9JIN6 / Calcium-activated potassium channel subunit beta-4 / Q86W47* / potassium calcium-activated channel subfamily M regulatory beta subunit 4*	/ complex
ENSMUSG00000037610	Kcnmb2 / Q9CZM9 / Calcium-activated potassium channel subunit beta-2 / Q9Y691* / AC117457.1* / potassium calcium-activated channel subfamily M regulatory beta subunit 2*	/ complex
ENSMUSG00000091091	Kcnmb3 / potassium calcium-activated channel subfamily M regulatory beta subunit 3 / Q9NPA1*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr