ENSG00000135643


Homo sapiens

Features
Gene ID: ENSG00000135643
  
Biological name :KCNMB4
  
Synonyms : KCNMB4 / potassium calcium-activated channel subfamily M regulatory beta subunit 4 / Q86W47
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q15
Gene start: 70366276
Gene end: 70434292
  
Corresponding Affymetrix probe sets: 219287_at (Human Genome U133 Plus 2.0 Array)   222857_s_at (Human Genome U133 Plus 2.0 Array)   235930_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000258111
Ensembl peptide - ENSP00000431137
NCBI entrez gene - 27345     See in Manteia.
OMIM - 605223
RefSeq - NM_014505
RefSeq Peptide - NP_055320
swissprot - Q86W47
swissprot - H0YC85
Ensembl - ENSG00000135643
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KCNMB4ENSGALG00000010044Gallus gallus
 Kcnmb4ENSMUSG00000054934Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNMB3 / Q9NPA1 / potassium calcium-activated channel subfamily M regulatory beta subunit 3ENSG0000017112130
KCNMB2 / Q9Y691 / potassium calcium-activated channel subfamily M regulatory beta subunit 2ENSG0000019758429
AC117457.1ENSG0000027516329
KCNMB1 / Q16558 / potassium calcium-activated channel subfamily M regulatory beta subunit 1ENSG0000014593620


Protein motifs (from Interpro)
Interpro ID Name
 IPR003930  Potassium channel, calcium-activated, BK, beta subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001508 action potential IDA
 biological_processGO:0005513 detection of calcium ion IDA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0019228 neuronal action potential IDA
 biological_processGO:0019229 regulation of vasoconstriction TAS
 biological_processGO:0046928 regulation of neurotransmitter secretion TAS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015269 calcium-activated potassium channel activity IEA
 molecular_functionGO:0015459 potassium channel regulator activity IBA


Pathways (from Reactome)
Pathway description
Ca2+ activated K+ channels
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138669 PRKG2 / Q13237 / protein kinase, cGMP-dependent, type II  / reaction
 ENSG00000135643 KCNMB4 / Q86W47 / potassium calcium-activated channel subfamily M regulatory beta subunit 4  / complex
 ENSG00000145936 KCNMB1 / Q16558 / potassium calcium-activated channel subfamily M regulatory beta subunit 1  / complex
 ENSG00000171121 KCNMB3 / Q9NPA1 / potassium calcium-activated channel subfamily M regulatory beta subunit 3  / complex
 ENSG00000197584 KCNMB2 / Q9Y691 / potassium calcium-activated channel subfamily M regulatory beta subunit 2  / complex
 ENSG00000156113 KCNMA1 / Q12791 / potassium calcium-activated channel subfamily M alpha 1  / complex
 ENSG00000185532 PRKG1 / Q13976 / protein kinase, cGMP-dependent, type I  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr