ENSG00000158571


Homo sapiens

Features
Gene ID: ENSG00000158571
  
Biological name :PFKFB1
  
Synonyms : 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 / P16118 / PFKFB1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: p11.21
Gene start: 54932961
Gene end: 54998534
  
Corresponding Affymetrix probe sets: 207537_at (Human Genome U133 Plus 2.0 Array)   237777_at (Human Genome U133 Plus 2.0 Array)   240883_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364131
Ensembl peptide - ENSP00000364145
Ensembl peptide - ENSP00000444074
Ensembl peptide - ENSP00000480232
NCBI entrez gene - 5207     See in Manteia.
OMIM - 311790
RefSeq - XM_017029578
RefSeq - NM_001271804
RefSeq - NM_001271805
RefSeq - NM_002625
RefSeq - XM_017029576
RefSeq - XM_017029577
RefSeq Peptide - NP_002616
RefSeq Peptide - NP_001258733
RefSeq Peptide - NP_001258734
swissprot - P16118
swissprot - Q4VBA9
swissprot - I1Z9G3
Ensembl - ENSG00000158571
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfkfb1ENSDARG00000037140Danio rerio
 si:dkey-96f10.1ENSDARG00000074457Danio rerio
 P70266ENSMUSG00000025271Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PFKFB4 / Q16877 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4ENSG0000011426875
O60825 / PFKFB2 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2ENSG0000012383667
PFKFB3 / Q16875 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3ENSG0000017052567


Protein motifs (from Interpro)
Interpro ID Name
 IPR001345  Phosphoglycerate/bisphosphoglycerate mutase, active site
 IPR003094  Fructose-2,6-bisphosphatase
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR013079  6-phosphofructo-2-kinase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006000 fructose metabolic process IEA
 biological_processGO:0006003 fructose 2,6-bisphosphate metabolic process IEA
 biological_processGO:0006094 gluconeogenesis TAS
 biological_processGO:0006096 glycolytic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033133 positive regulation of glucokinase activity IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0045820 negative regulation of glycolytic process TAS
 biological_processGO:0045821 positive regulation of glycolytic process TAS
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003873 6-phosphofructo-2-kinase activity IEA
 molecular_functionGO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0070095 fructose-6-phosphate binding IEA


Pathways (from Reactome)
Pathway description
PKA-mediated phosphorylation of key metabolic factors
PP2A-mediated dephosphorylation of key metabolic factors
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112640 Q14738 / PPP2R5D / protein phosphatase 2 regulatory subunit Bdelta  / reaction
 ENSG00000072062 P17612 / PRKACA / protein kinase cAMP-activated catalytic subunit alpha  / reaction
 ENSG00000142875 P22694 / PRKACB / protein kinase cAMP-activated catalytic subunit beta  / reaction
 ENSG00000158571 P16118 / PFKFB1 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1  / complex
 ENSG00000165059 P22612 / PRKACG / protein kinase cAMP-activated catalytic subunit gamma  / reaction






 

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