ENSMUSG00000025271


Mus musculus

Features
Gene ID: ENSMUSG00000025271
  
Biological name :Pfkfb1
  
Synonyms : 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 / P70266 / Pfkfb1
  
Possible biological names infered from orthology : P16118
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F3
Gene start: 150588229
Gene end: 150643878
  
Corresponding Affymetrix probe sets: 10602385 (MoGene1.0st)   1427213_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108333
Ensembl peptide - ENSMUSP00000115844
Ensembl peptide - ENSMUSP00000079692
NCBI entrez gene - 18639     See in Manteia.
MGI - MGI:107816
RefSeq - XM_006528755
RefSeq - XM_006528756
RefSeq - XM_011247791
RefSeq - NM_008824
RefSeq Peptide - NP_032850
swissprot - P70266
swissprot - A2AFM8
swissprot - A2AFM9
Ensembl - ENSMUSG00000025271
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfkfb1ENSDARG00000037140Danio rerio
 si:dkey-96f10.1ENSDARG00000074457Danio rerio
 P16118ENSG00000158571Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pfkfb4 / Q6DTY7 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 / Q16877*ENSMUSG0000002564875
Pfkfb3 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 / Q16875*ENSMUSG0000002677370
Pfkfb2 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 / O60825*ENSMUSG0000002640968
Gm29427 / O60825* / PFKFB2* / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2*ENSMUSG0000010190453


Protein motifs (from Interpro)
Interpro ID Name
 IPR001345  Phosphoglycerate/bisphosphoglycerate mutase, active site
 IPR003094  Fructose-2,6-bisphosphatase
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR013079  6-phosphofructo-2-kinase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006000 fructose metabolic process IEA
 biological_processGO:0006003 fructose 2,6-bisphosphate metabolic process ISO
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033133 positive regulation of glucokinase activity IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051591 response to cAMP IEA
 cellular_componentGO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003873 6-phosphofructo-2-kinase activity ISO
 molecular_functionGO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0070095 fructose-6-phosphate binding IEA


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025271 P70266 / Pfkfb1 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 / P16118*  / complex






 

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