ENSG00000114268


Homo sapiens

Features
Gene ID: ENSG00000114268
  
Biological name :PFKFB4
  
Synonyms : 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 / PFKFB4 / Q16877
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 48517684
Gene end: 48562015
  
Corresponding Affymetrix probe sets: 206246_at (Human Genome U133 Plus 2.0 Array)   228499_at (Human Genome U133 Plus 2.0 Array)   232674_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393047
Ensembl peptide - ENSP00000389169
Ensembl peptide - ENSP00000400772
Ensembl peptide - ENSP00000415764
Ensembl peptide - ENSP00000407657
Ensembl peptide - ENSP00000232375
Ensembl peptide - ENSP00000373240
Ensembl peptide - ENSP00000388394
NCBI entrez gene - 5210     See in Manteia.
OMIM - 605320
RefSeq - XM_017006617
RefSeq - NM_001317134
RefSeq - NM_001317135
RefSeq - NM_001317136
RefSeq - NM_001317137
RefSeq - NM_001317138
RefSeq - NM_004567
RefSeq - XM_011533829
RefSeq - XM_017006614
RefSeq - XM_017006615
RefSeq - XM_017006616
RefSeq Peptide - NP_001304066
RefSeq Peptide - NP_001304067
RefSeq Peptide - NP_004558
RefSeq Peptide - NP_001304064
RefSeq Peptide - NP_001304065
RefSeq Peptide - NP_001304063
swissprot - Q66S35
swissprot - C9JJ23
swissprot - C9K0D8
swissprot - C9JX77
swissprot - F8WC12
swissprot - F8WDY1
swissprot - Q16877
Ensembl - ENSG00000114268
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfkfb4aENSDARG00000055540Danio rerio
 pfkfb4bENSDARG00000029075Danio rerio
 PFKFB4ENSGALG00000002099Gallus gallus
 Pfkfb4ENSMUSG00000025648Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P16118 / PFKFB1 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1ENSG0000015857175
O60825 / PFKFB2 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2ENSG0000012383667
PFKFB3 / Q16875 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3ENSG0000017052567


Protein motifs (from Interpro)
Interpro ID Name
 IPR001345  Phosphoglycerate/bisphosphoglycerate mutase, active site
 IPR003094  Fructose-2,6-bisphosphatase
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR013079  6-phosphofructo-2-kinase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006000 fructose metabolic process IEA
 biological_processGO:0006003 fructose 2,6-bisphosphate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0045821 positive regulation of glycolytic process TAS
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003873 6-phosphofructo-2-kinase activity IEA
 molecular_functionGO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114268 PFKFB4 / Q16877 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4  / complex






 

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