ENSG00000123836


Homo sapiens

Features
Gene ID: ENSG00000123836
  
Biological name :PFKFB2
  
Synonyms : 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 / O60825 / PFKFB2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 207034366
Gene end: 207081024
  
Corresponding Affymetrix probe sets: 207931_s_at (Human Genome U133 Plus 2.0 Array)   209992_at (Human Genome U133 Plus 2.0 Array)   226733_at (Human Genome U133 Plus 2.0 Array)   238450_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484769
Ensembl peptide - ENSP00000408717
Ensembl peptide - ENSP00000484988
Ensembl peptide - ENSP00000439420
Ensembl peptide - ENSP00000356046
Ensembl peptide - ENSP00000356047
NCBI entrez gene - 5208     See in Manteia.
OMIM - 171835
RefSeq - NM_006212
RefSeq - NM_001018053
RefSeq Peptide - NP_001018063
RefSeq Peptide - NP_006203
swissprot - A0A087X2H4
swissprot - O60825
swissprot - A0A087X278
swissprot - F6RAZ1
swissprot - F6XNB3
Ensembl - ENSG00000123836
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfkfb2aENSDARG00000023840Danio rerio
 pfkfb2bENSDARG00000002037Danio rerio
 PFKFB2ENSGALG00000001117Gallus gallus
 Gm29427ENSMUSG00000101904Mus musculus
 Pfkfb2ENSMUSG00000026409Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PFKFB3 / Q16875 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3ENSG0000017052566
P16118 / PFKFB1 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1ENSG0000015857163
PFKFB4 / Q16877 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4ENSG0000011426862


Protein motifs (from Interpro)
Interpro ID Name
 IPR001345  Phosphoglycerate/bisphosphoglycerate mutase, active site
 IPR003094  Fructose-2,6-bisphosphatase
 IPR013078  Histidine phosphatase superfamily, clade-1
 IPR013079  6-phosphofructo-2-kinase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029033  Histidine phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006000 fructose metabolic process TAS
 biological_processGO:0006003 fructose 2,6-bisphosphate metabolic process IEA
 biological_processGO:0006007 glucose catabolic process IEA
 biological_processGO:0006089 lactate metabolic process IEA
 biological_processGO:0006090 pyruvate metabolic process IEA
 biological_processGO:0006096 glycolytic process IDA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0033133 positive regulation of glucokinase activity IEA
 biological_processGO:0045821 positive regulation of glycolytic process TAS
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003873 6-phosphofructo-2-kinase activity TAS
 molecular_functionGO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123836 O60825 / PFKFB2 / 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2  / complex






 

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