ENSDARG00000055536


Danio rerio

Features
Gene ID: ENSDARG00000055536
  
Biological name :otub1a
  
Synonyms : otub1a / OTU deubiquitinase, ubiquitin aldehyde binding 1a
  
Possible biological names infered from orthology : OTUB1 / OTU deubiquitinase, ubiquitin aldehyde binding 1 / Q7TQI3 / Q96FW1 / Ubiquitin thioesterase OTUB1
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 28502340
Gene end: 28513055
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000072363
Ensembl peptide - ENSDARP00000115717
NCBI entrez gene - 436684     See in Manteia.
RefSeq - NM_001002411
RefSeq Peptide - NP_001002411
swissprot - F1Q6S6
swissprot - Q6DH16
ZFIN ID - ZDB-GENE-040718-108
Ensembl - ENSDARG00000055536
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OTUB1ENSG00000167770Homo sapiens
 Otub1ENSMUSG00000024767Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
otub1b / OTU deubiquitinase, ubiquitin aldehyde binding 1b / OTUB1* / Q7TQI3* / Q96FW1* / Ubiquitin thioesterase OTUB1 * / OTU deubiquitinase, ubiquitin aldehyde binding 1*ENSDARG0000001146283


Protein motifs (from Interpro)
Interpro ID Name
 IPR003323  OTU domain
 IPR016615  Ubiquitin thioesterase Otubain
 IPR019400  Peptidase C65, otubain
 IPR030298  Ubiquitin thioesterase OTUB1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IBA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019784 NEDD8-specific protease activity IBA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0043130 ubiquitin binding IBA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
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 ZFA:0000106 extension extension decreased thickness , abnormal
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 ZFA:0000155 somite somite fused with somite , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001115 trunk trunk decreased thickness , abnormal
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 ZFA:0001117 post-vent region post-vent region curled , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000016867 rnf128a / ring finger protein 128a / Q8N7C7* / Q8TEB7* / Q8WVZ7* / Q9D304* / RNF148* / G3X9R7* / Q14B02* / RNF128* / RNF133* / ring finger protein 148* / ring finger protein 133* / E3 ubiqu...  / complex
 ENSDARG00000004111 esr1 / estrogen receptor 1 / P03372* / P19785* / Estrogen receptor *  / complex / reaction
 ENSDARG00000038576 ube2d1b / ubiquitin-conjugating enzyme E2D 1b / UBE2D1* / P51668* / P61080* / ubiquitin conjugating enzyme E2 D1*  / complex / reaction
 ENSDARG00000063719 usp8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*  / complex






 

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