ENSDARG00000063719
Danio rerio ubiquitin domain usp8 hydrolase specific protease protein activity erbb regulation peptidase c carboxyl-terminal rhodanese-like usp dimerisation conserved site ubiquitin-dependent catabolic process deubiquitination thiol-dependent ubiquitinyl downregulation signaling fzd ubiquitination ub-specific processing proteases
Features See expression report in BioGPS See gene description in Wikigenes See co-cited genes in PubMed Ortholog prediction (from Ensembl )Paralog prediction (from Ensembl ) usp2b / ubiquitin specific peptidase 2b / USP2* / O75604* / O88623* / ubiquitin specific peptidase 2* ENSDARG00000074120 15 usp2a / ubiquitin specific peptidase 2a / USP2* / O75604* / O88623* / ubiquitin specific peptidase 2* ENSDARG00000020107 14 usp33 / A5PMR2 / ubiquitin specific peptidase 33 / Q8R5K2* / Q8TEY7* ENSDARG00000016163 12 usp20 / A5PN09 / ubiquitin specific peptidase 20 / Q9Y2K6* ENSDARG00000027501 12 usp45 / ubiquitin specific peptidase 45 / Q70EL2* / Q8K387* / ubiquitin specific petidase 45* ENSDARG00000075013 12 usp16 / A8HAL1 / ubiquitin specific peptidase 16 / Q99LG0* / Q9Y5T5* ENSDARG00000060633 11 usp21 / ubiquitin specific peptidase 21 / Q9UK80* ENSDARG00000094280 11
Protein motifs (from Interpro ) IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase IPR001763 Rhodanese-like domain IPR015063 USP8 dimerisation domain IPR018200 Ubiquitin specific protease, conserved site IPR028889 Ubiquitin specific protease domain
Gene Ontology (GO ) nitrogen compound metabolic process catabolic process cellular metabolic process primary metabolic process organic substance metabolic process nitrogen compound metabolic process catabolic process cellular metabolic process primary metabolic process organic substance metabolic process nitrogen compound metabolic process catabolic process cellular metabolic process primary metabolic process organic substance metabolic process nitrogen compound metabolic process catabolic process cellular metabolic process primary metabolic process organic substance metabolic process nitrogen compound metabolic process catabolic process cellular metabolic process primary metabolic process organic substance metabolic process nitrogen compound metabolic process catabolic process cellular metabolic process primary metabolic process organic substance metabolic process nitrogen compound metabolic process catabolic process cellular metabolic process primary metabolic process organic substance metabolic process nitrogen compound metabolic process catabolic process cellular metabolic process primary metabolic process organic substance metabolic process nitrogen compound metabolic process catabolic process cellular metabolic process primary metabolic process organic substance metabolic process nitrogen compound metabolic process catabolic process cellular metabolic process primary metabolic process organic substance metabolic process nitrogen compound metabolic nitrogen compound metabolic process catabolic processcatabolic process cellular metabolic processcellular metabolic process primary metabolic processprimary metabolic process organic substance metabolic organic substance metabolic process catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a protein hydrolase activity catalytic activity, acting on a proteincatalytic activity, acting on a protein hydrolase activityhydrolase activity
Pathways (from Reactome )Phenotype (from MGI , Zfin or HPO ) ZFA:0000012 central nervous system central nervous system necrotic , abnormal
Show ZFA:0000054 pericardium pericardium edematous , abnormal
Show ZFA:0000155 somite somite fused with somite , abnormal
Show ZFA:0001094 whole organism whole organism decreased size , abnormal
Show ZFA:0001115 trunk trunk necrotic , abnormal
Show ZFA:0001117 post-vent region post-vent region curled , abnormal
Show ZFA:0009052 motor neuron motor neuron axon branched , abnormal
Show
Interacting proteins (from Reactome ) ENSDARG00000011462 otub1b / OTU deubiquitinase, ubiquitin aldehyde binding 1b / OTUB1* / Q7TQI3* / Q96FW1* / Ubiquitin thioesterase OTUB1 * / OTU deubiquitinase, ubiquitin aldehyde binding 1* / complex ENSDARG00000005318 stam2 / signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 / O75886* / O88811* / signal transducing adaptor molecule 2* / complex ENSDARG00000016867 rnf128a / ring finger protein 128a / Q8N7C7* / Q8TEB7* / Q8WVZ7* / Q9D304* / RNF148* / G3X9R7* / Q14B02* / RNF128* / RNF133* / ring finger protein 148* / ring finger protein 133* / E3 ubiqu... / complex ENSDARG00000055536 otub1a / OTU deubiquitinase, ubiquitin aldehyde binding 1a / OTUB1* / Q7TQI3* / Q96FW1* / Ubiquitin thioesterase OTUB1 * / OTU deubiquitinase, ubiquitin aldehyde binding 1* / complex ENSDARG00000075625 lrig1 / leucine-rich repeats and immunoglobulin-like domains 1 / P70193* / Q96JA1* / Leucine-rich repeats and immunoglobulin-like domains protein 1 * / reaction ENSDARG00000020960 hgs / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 * / complex ENSDARG00000070903 met / MET proto-oncogene, receptor tyrosine kinase / P08581* / reaction
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