ENSDARG00000016163


Danio rerio

Features
Gene ID: ENSDARG00000016163
  
Biological name :usp33
  
Synonyms : A5PMR2 / ubiquitin specific peptidase 33 / usp33
  
Possible biological names infered from orthology : Q8R5K2 / Q8TEY7
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 8717155
Gene end: 8777496
  
Corresponding Affymetrix probe sets: Dr.5859.1.A1_at (Zebrafish Array)   NM_213227_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000014516
Ensembl peptide - ENSDARP00000118654
Ensembl peptide - ENSDARP00000118131
NCBI entrez gene - 406508     See in Manteia.
RefSeq - NM_213227
RefSeq Peptide - NP_998392
swissprot - A5PMR4
swissprot - A5PMR3
swissprot - A5PMR2
ZFIN ID - ZDB-GENE-040426-2323
Ensembl - ENSDARG00000016163
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 USP33ENSGALG00000008974Gallus gallus
 USP33ENSG00000077254Homo sapiens
 Usp33ENSMUSG00000025437Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
usp20 / A5PN09 / ubiquitin specific peptidase 20 / Q9Y2K6*ENSDARG0000002750161
usp16 / A8HAL1 / ubiquitin specific peptidase 16 / Q99LG0* / Q9Y5T5*ENSDARG0000006063315
usp45 / ubiquitin specific peptidase 45 / Q70EL2* / Q8K387* / ubiquitin specific petidase 45*ENSDARG0000007501315
usp2a / ubiquitin specific peptidase 2a / USP2* / O75604* / O88623* / ubiquitin specific peptidase 2*ENSDARG0000002010714
usp8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*ENSDARG0000006371914
usp2b / ubiquitin specific peptidase 2b / USP2* / O75604* / O88623* / ubiquitin specific peptidase 2*ENSDARG0000007412013
usp21 / ubiquitin specific peptidase 21 / Q9UK80*ENSDARG0000009428013


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007411 axon guidance ISS
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway ISS
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0016579 protein deubiquitination ISS
 biological_processGO:0051298 centrosome duplication ISS
 biological_processGO:0070536 protein K63-linked deubiquitination ISS
 biological_processGO:0071108 protein K48-linked deubiquitination ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity ISS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curled , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011545 arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex
 ENSDARG00000039215 arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr