ENSDARG00000011545


Danio rerio

Features
Gene ID: ENSDARG00000011545
  
Biological name :arrb2b
  
Synonyms : arrb2b / arrestin, beta 2b
  
Possible biological names infered from orthology : ARRB2 / arrestin beta 2 / Beta-arrestin-2 / P32121 / Q91YI4
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 25920792
Gene end: 26005691
  
Corresponding Affymetrix probe sets: Dr.5074.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000024694
NCBI entrez gene - 394099     See in Manteia.
swissprot - Q7T2D2
ZFIN ID - ZDB-GENE-040426-1332
Ensembl - ENSDARG00000011545
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARRB2ENSG00000141480Homo sapiens
 Arrb2ENSMUSG00000060216Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *ENSDARG0000003921589
arrb1 / arrestin, beta 1 / P49407*ENSDARG0000004324177
saga / S-antigen; retina and pineal gland (arrestin) a / SAG* / P20443* / P10523* / S-antigen visual arrestin* / S-antigen, retina and pineal gland (arrestin)*ENSDARG0000001261054
sagb / S-antigen; retina and pineal gland (arrestin) b / SAG* / P10523* / S-antigen visual arrestin*ENSDARG0000003837852
arr3a / arrestin 3a, retinal (X-arrestin) / ARR3* / Q9EQP6* / P36575* / arrestin 3* / Arrestin-C *ENSDARG0000005651148
arr3b / arrestin 3b, retinal (X-arrestin) / ARR3* / Q9EQP6* / P36575* / arrestin 3* / Arrestin-C *ENSDARG0000009847545


Protein motifs (from Interpro)
Interpro ID Name
 IPR000698  Arrestin
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014753  Arrestin, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR017864  Arrestin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001919 regulation of receptor recycling IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0008589 regulation of smoothened signaling pathway IMP
 biological_processGO:1900136 regulation of chemokine activity IGI


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WNT5A-dependent internalization of FZD4
MAP2K and MAPK activation
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
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 ZFA:0000155 somite somite disorganized , abnormal
somite atrophied , abnormal
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 ZFA:0001086 muscle pioneer muscle pioneer decreased amount , abnormal
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 ZFA:0001115 trunk trunk curved , abnormal
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 ZFA:0009116 slow muscle cell slow muscle cell decreased amount , abnormal
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 ZFA:0009288 primordial germ cell primordial germ cell mislocalised medially , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002790 Q6NWK2 / ap2m1a / ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000016163 usp33 / A5PMR2 / ubiquitin specific peptidase 33 / Q8R5K2* / Q8TEY7*  / complex
 ENSDARG00000035152 ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction
 ENSDARG00000007436 avpr2aa / arginine vasopressin receptor 2a, duplicate a / AVPR2* / O88721* / P30518* / arginine vasopressin receptor 2*  / complex / reaction
 ENSDARG00000026967 ap2s1 / adaptor-related protein complex 2, sigma 1 subunit / P53680* / P62743* / AP-2 complex subunit sigma *  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000002952 smo / smoothened, frizzled class receptor / P56726* / Q99835*  / complex
 ENSDARG00000060012 f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *  / complex / reaction
 ENSDARG00000033899 ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / reaction / complex
 ENSDARG00000087538 kif3a / kinesin family member 3A / P28741* / Q9Y496* / Kinesin-like protein KIF3A *  / complex
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000116374 chrm2b / cholinergic receptor, muscarinic 2b / CHRM2* / Q9ERZ4* / P08172* / cholinergic receptor muscarinic 2* / cholinergic receptor, muscarinic 2, cardiac*  / complex / reaction
 ENSDARG00000098612 chrm2a / cholinergic receptor, muscarinic 2a / CHRM2* / Q9ERZ4* / P08172* / cholinergic receptor muscarinic 2* / cholinergic receptor, muscarinic 2, cardiac*  / complex / reaction






 

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