ENSDARG00000060012


Danio rerio

Features
Gene ID: ENSDARG00000060012
  
Biological name :f2r
  
Synonyms : coagulation factor II (thrombin) receptor / f2r
  
Possible biological names infered from orthology : P25116 / P30558 / Proteinase-activated receptor 1
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 46196147
Gene end: 46198034
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000078547
NCBI entrez gene - 558477     See in Manteia.
RefSeq - NM_001114846
RefSeq Peptide - NP_001108318
swissprot - A2BIP6
ZFIN ID - ZDB-GENE-060526-30
Ensembl - ENSDARG00000060012
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F2RENSGALG00000014983Gallus gallus
 F2RENSG00000181104Homo sapiens
 F2rENSMUSG00000048376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
si:dkey-163m14.4ENSDARG0000008746937
si:dkey-163m14.6ENSDARG0000009004137
zgc:171965ENSDARG0000007763836
si:dkey-163m14.7ENSDARG0000008623636
si:dkey-163m14.2ENSDARG0000005950735
si:dkey-163m14.10ENSDARG0000008626235
f2rl1.2 / coagulation factor II (thrombin) receptor-like 1, tandem duplicate 2 / F2RL1* / P55086* / P55085* / F2R like trypsin receptor 1* / Proteinase-activated receptor 2 *ENSDARG0000007754030
f2rl1.1 / coagulation factor II (thrombin) receptor-like 1, tandem duplicate 1 / F2RL1* / P55086* / P55085* / F2R like trypsin receptor 1* / Proteinase-activated receptor 2 *ENSDARG0000006885627
p2ry8 / P2Y receptor family member 8 / Q86VZ1*ENSDARG0000005556026
F2RL3 / si:ch211-132p1.2 / O88634* / Q96RI0* / Proteinase-activated receptor 4 * / F2R like thrombin or trypsin receptor 3*ENSDARG0000007939925
CABZ01071020.1 / F2RL2* / O00254* / coagulation factor II thrombin receptor like 2*ENSDARG0000007947223
f2rl2 / coagulation factor II (thrombin) receptor-like 2 / O00254*ENSDARG0000009052423
gpr4 / G protein-coupled receptor 4 / P46093* / Q8BUD0*ENSDARG0000007947921
si:dkey-211g8.7 / FFAR3* / GPR42* / FFAR2* / Q8VCK6* / O15529* / O15552* / Q3UFD7* / O14843* / free fatty acid receptor 2* / free fatty acid receptor 3* / G protein-coupled receptor 42 (gen...ENSDARG0000005853519
si:dkey-211g8.6 / FFAR3* / GPR42* / FFAR2* / Q8VCK6* / O15529* / O15552* / Q3UFD7* / O14843* / free fatty acid receptor 2* / free fatty acid receptor 3* / G protein-coupled receptor 42 (gen...ENSDARG0000006308819
si:dkey-165a24.9ENSDARG0000009005219
gpr132b / G protein-coupled receptor 132b / Q9Z282* / GPR132* / Q9UNW8* / G protein-coupled receptor 132*ENSDARG0000010354019
gpr132a / G protein-coupled receptor 132a / Q9Z282* / GPR132* / Q9UNW8* / G protein-coupled receptor 132*ENSDARG0000002149718
si:ch211-231m23.4 / FFAR3* / GPR42* / FFAR2* / Q8VCK6* / O15529* / O15552* / Q3UFD7* / O14843* / free fatty acid receptor 2* / free fatty acid receptor 3* / G protein-coupled receptor 42 (g...ENSDARG0000004129218
gpr65 / G protein-coupled receptor 65 / Q8IYL9*ENSDARG0000004595717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000935  Thrombin receptor
 IPR003912  Protease-activated receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IBA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA
 biological_processGO:0070493 thrombin-activated receptor signaling pathway IEA
 biological_processGO:0072358 cardiovascular system development IMP
 biological_processGO:0098508 endothelial to hematopoietic transition IMP
 biological_processGO:1902037 negative regulation of hematopoietic stem cell differentiation IMP
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0015057 thrombin-activated receptor activity IDA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood increased accumulation blood island , abnormal
blood increased accumulation caudal vein , abnormal
blood increased accumulation post-vent region , abnormal
blood increased accumulation vasculature , abnormal
Show

 ZFA:0000014 dorsal aorta dorsal aorta decreased size , abnormal
Show

 ZFA:0000076 swim bladder swim bladder physical object quality , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000128 midbrain midbrain hemorrhagic , abnormal
Show

 ZFA:0000180 caudal vein caudal vein disorganized , abnormal
caudal vein dilated , abnormal
caudal vein malformed , abnormal
caudal vein functionality , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein functionality , abnormal
Show

 ZFA:0000547 mouth mouth structure , abnormal
Show

 ZFA:0001117 post-vent region post-vent region bent , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel collapsed , abnormal
Show

 ZFA:0005020 central artery central artery hemorrhagic , abnormal
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic stem cell increased amount , abnormal
Show

 ZFA:0005094 optic choroid vascular plexus optic choroid vascular plexus hemorrhagic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011487 gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000025826 gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*  / complex / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction / complex
 ENSDARG00000011545 arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction
 ENSDARG00000060012 f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *  / reaction
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / complex / reaction
 ENSDARG00000043241 arrb1 / arrestin, beta 1 / P49407*  / complex / reaction
 ENSDARG00000090524 f2rl2 / coagulation factor II (thrombin) receptor-like 2 / O00254*  / reaction
 ENSDARG00000073765 gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*  / complex / reaction
 ENSDARG00000079472 CABZ01071020.1 / F2RL2* / O00254* / coagulation factor II thrombin receptor like 2*  / reaction
 ENSDARG00000079399 F2RL3 / si:ch211-132p1.2 / O88634* / Q96RI0* / Proteinase-activated receptor 4 * / F2R like thrombin or trypsin receptor 3*  / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / complex / reaction
 ENSDARG00000025013 gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*  / reaction / complex
 ENSDARG00000016364 gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...  / reaction / complex
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / complex / reaction
 ENSDARG00000039215 arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr