Manteia

ENSDARG00000025826

Danio rerio

Features

Gene ID:	ENSDARG00000025826

Biological name :	gna12a

Synonyms :	gna12a / guanine nucleotide binding protein (G protein) alpha 12a

Possible biological names infered from orthology :	GNA12 / G protein subunit alpha 12 / guanine nucleotide binding protein, alpha 12 / P27600 / Q03113

Species:	Danio rerio

Chr. number:	3
Strand:	1
Band:
Gene start:	41647637
Gene end:	41706238

Corresponding Affymetrix probe sets:	Dr.12041.1.A1_at (Zebrafish Array)

Cross references:	Ensembl peptide - ENSDARP00000050331 NCBI entrez gene - 503589 See in Manteia. RefSeq - NM_001013277 RefSeq Peptide - NP_001013295 swissprot - Q5YKG4 ZFIN ID - ZDB-GENE-050221-1 Ensembl - ENSDARG00000025826

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
GNA12	ENSGALG00000004368	Gallus gallus
GNA12	ENSG00000146535	Homo sapiens
Gna12	ENSMUSG00000000149	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*	ENSDARG00000073765	62
gna13b / guanine nucleotide binding protein (G protein), alpha 13b / GNA13* / Q14344* / G protein subunit alpha 13*	ENSDARG00000037924	59
gna11b / guanine nucleotide binding protein (G protein), alpha 11b (Gq class)	ENSDARG00000053326	42
gna11a / guanine nucleotide binding protein (G protein), alpha 11a (Gq class)	ENSDARG00000010002	41
gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*	ENSDARG00000025013	41
gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*	ENSDARG00000011487	40
gnao1a / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...	ENSDARG00000016676	38
gna14 / guanine nucleotide binding protein (G protein), alpha 14	ENSDARG00000035178	37
gnaia / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a	ENSDARG00000044760	37
GNAZ / G protein subunit alpha z / P19086*	ENSDARG00000099844	37
gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...	ENSDARG00000016364	36
gnai2b / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...	ENSDARG00000017294	36
gnai2a / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...	ENSDARG00000018174	36
gnai1 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	ENSDARG00000021647	36
gnao1b / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...	ENSDARG00000036058	36
gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 / P20612* / P11488* / G protein subunit alpha transducin 1* / guanine nucleotide binding pro...	ENSDARG00000044199	36
gna15.2 / gna15.3 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 2 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide b...	ENSDARG00000056654	36
gnav1 / guanine nucleotide binding protein (G protein) alpha v1	ENSDARG00000043006	35
gnai3 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 / GNAI1* / B2RSH2* / P08754* / P63096* / Q9DC51* / G protein subunit alpha i1* / G protein su...	ENSDARG00000030644	34
gnat2 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 / P50149* / P19087* / G protein subunit alpha transducin 2* / guanine nucleotide binding pro...	ENSDARG00000042529	34

Protein motifs (from Interpro)

Interpro ID	Name
IPR000469	G-protein alpha subunit, group 12/13
IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
IPR011025	G protein alpha subunit, helical insertion
IPR027417	P-loop containing nucleoside triphosphate hydrolase

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001702	gastrulation with mouth forming second	IMP
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	IBA
biological_process	GO:0007264	small GTPase mediated signal transduction	IEA
biological_process	GO:0007266	Rho protein signal transduction	IMP
biological_process	GO:0009826	unidimensional cell growth	IGI
biological_process	GO:0014003	oligodendrocyte development	IGI
biological_process	GO:0032956	regulation of actin cytoskeleton organization	IGI
biological_process	GO:0042074	cell migration involved in gastrulation	IGI
biological_process	GO:0043149	stress fiber assembly	IMP
biological_process	GO:0055113	epiboly involved in gastrulation with mouth forming second	IGI
biological_process	GO:0060973	cell migration involved in heart development	IGI
biological_process	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	IGI
cellular_component	GO:0005834	heterotrimeric G-protein complex	IBA
cellular_component	GO:0031526	brush border membrane	IBA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0001664	G-protein coupled receptor binding	IEA
molecular_function	GO:0003924	GTPase activity	IBA
molecular_function	GO:0004871	obsolete signal transducer activity	IBA
molecular_function	GO:0005525	GTP binding	IEA
molecular_function	GO:0019001	guanyl nucleotide binding	IEA
molecular_function	GO:0031683	G-protein beta/gamma-subunit complex binding	IBA
molecular_function	GO:0031752	D5 dopamine receptor binding	IBA

Pathways (from Reactome)

Pathway description

G alpha (12/13) signalling events

Thrombin signalling through proteinase activated receptors (PARs)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000075	spinal cord	spinal cord oligodendrocyte development decreased occurrence , abnormal	Show
ZFA:0000114	heart	heart duplicated , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000024101	adra1d / adrenoceptor alpha 1D / P25100*	/ complex / reaction
ENSDARG00000011317	adra1ba / adrenoceptor alpha 1Ba / ADRA1B* / P35368* / adrenoceptor alpha 1B*	/ complex / reaction
ENSDARG00000030532	arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*	/ complex / reaction
ENSDARG00000028725	adra1aa / adrenoceptor alpha 1Aa / ADRA1A* / P35348* / adrenoceptor alpha 1A*	/ complex / reaction
ENSDARG00000060012	f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *	/ complex / reaction
ENSDARG00000056831	gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*	/ complex / reaction
ENSDARG00000090524	f2rl2 / coagulation factor II (thrombin) receptor-like 2 / O00254*	/ complex / reaction
ENSDARG00000079472	CABZ01071020.1 / F2RL2* / O00254* / coagulation factor II thrombin receptor like 2*	/ complex / reaction
ENSDARG00000079399	F2RL3 / si:ch211-132p1.2 / O88634* / Q96RI0* / Proteinase-activated receptor 4 * / F2R like thrombin or trypsin receptor 3*	/ complex / reaction
ENSDARG00000090454	gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*	/ complex / reaction
ENSDARG00000027638	adra1ab / adrenoceptor alpha 1Ab / ADRA1A* / P35348* / P97718* / adrenoceptor alpha 1A* / Alpha-1A adrenergic receptor *	/ complex / reaction
ENSDARG00000100913	arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b / Q8R4H2* / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12* / Mus musculus Rho guanine nucleotide exchange fact...	/ complex / reaction
ENSDARG00000104372	gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr