ENSDARG00000042529


Danio rerio

Features
Gene ID: ENSDARG00000042529
  
Biological name :gnat2
  
Synonyms : gnat2 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
  
Possible biological names infered from orthology : G protein subunit alpha transducin 2 / guanine nucleotide binding protein, alpha transducing 2 / P19087 / P50149
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 25225590
Gene end: 25247284
  
Corresponding Affymetrix probe sets: Dr.9881.1.S1_at (Zebrafish Array)   Dr.9881.2.A1_at (Zebrafish Array)   NM_131869_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000113426
Ensembl peptide - ENSDARP00000062362
NCBI entrez gene - 140429     See in Manteia.
RefSeq - NM_131869
RefSeq Peptide - NP_571944
swissprot - B8JL40
swissprot - Q90WX5
ZFIN ID - ZDB-GENE-011128-10
Ensembl - ENSDARG00000042529
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNAT2ENSGALG00000038084Gallus gallus
 GNAT2ENSG00000134183Homo sapiens
 Gnat2ENSMUSG00000009108Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 / P20612* / P11488* / G protein subunit alpha transducin 1* / guanine nucleotide binding pro...ENSDARG0000004419976
gnai2b / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...ENSDARG0000001729464
gnai2a / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...ENSDARG0000001817464
gnai1 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1ENSDARG0000002164764
gnai3 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 / GNAI1* / B2RSH2* / P08754* / P63096* / Q9DC51* / G protein subunit alpha i1* / G protein su...ENSDARG0000003064462
gnaia / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide aENSDARG0000004476062
gnao1a / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...ENSDARG0000001667659
gnao1b / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...ENSDARG0000003605857
GNAZ / G protein subunit alpha z / P19086*ENSDARG0000009984455
gna11a / guanine nucleotide binding protein (G protein), alpha 11a (Gq class)ENSDARG0000001000248
gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*ENSDARG0000001148748
gna11b / guanine nucleotide binding protein (G protein), alpha 11b (Gq class)ENSDARG0000005332648
gnav1 / guanine nucleotide binding protein (G protein) alpha v1ENSDARG0000004300647
gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*ENSDARG0000002501346
gna14 / guanine nucleotide binding protein (G protein), alpha 14ENSDARG0000003517844
gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...ENSDARG0000001636441
gna13b / guanine nucleotide binding protein (G protein), alpha 13b / GNA13* / Q14344* / G protein subunit alpha 13*ENSDARG0000003792440
gna15.2 / gna15.3 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 2 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide b...ENSDARG0000005665438
gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*ENSDARG0000007376538
gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*ENSDARG0000002582636


Protein motifs (from Interpro)
Interpro ID Name
 IPR001019  Guanine nucleotide binding protein (G-protein), alpha subunit
 IPR001408  G-protein alpha subunit, group I
 IPR011025  G protein alpha subunit, helical insertion
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0050908 detection of light stimulus involved in visual perception IMP
 cellular_componentGO:0001750 photoreceptor outer segment IBA
 cellular_componentGO:0001917 photoreceptor inner segment IBA
 cellular_componentGO:0005834 heterotrimeric G-protein complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019001 guanyl nucleotide binding IEA
 molecular_functionGO:0031683 G-protein beta/gamma-subunit complex binding IEA


Pathways (from Reactome)
Pathway description
PLC beta mediated events
G-protein activation
Ca2+ pathway
G alpha (i) signalling events
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye quality , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

 ZFA:0009091 melanocyte melanocyte morphology , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000000380 pde6a / phosphodiesterase 6A, cGMP-specific, rod, alpha / P16499* / phosphodiesterase 6A*  / complex
 ENSDARG00000002193 rho / P35359 / rhodopsin / P08100*  / complex / reaction
 ENSDARG00000044861 Q8AYN0 / opn1lw2 / opsin 1 (cone pigments), long-wave-sensitive, 2 / OPN1MW* / P04000* / P0DN77* / O35599* / P0DN78* / P04001* / OPN1LW* / OPN1MW3* / OPN1MW2* / opsin 1, long wave sensitive...  / complex / reaction
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / complex
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / complex
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / complex
 ENSDARG00000044862 Q9W6A7 / opn1lw1 / opsin 1 (cone pigments), long-wave-sensitive, 1 / OPN1MW* / P04000* / P0DN77* / O35599* / P0DN78* / P04001* / OPN1LW* / OPN1MW3* / OPN1MW2* / opsin 1, long wave sensitive...  / complex / reaction
 ENSDARG00000070666 rhol / rhodopsin, like / RHO* / P15409* / P08100* / rhodopsin*  / complex / reaction
 ENSDARG00000011671 pde6b / phosphodiesterase 6B, cGMP-specific, rod, beta / P35913* / P23440* / phosphodiesterase 6B* / phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide*  / complex
 ENSDARG00000101984 pde6gb / phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b / PDE6G* / P18545* / phosphodiesterase 6G*  / complex






 

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