ENSDARG00000090454


Danio rerio

Features
Gene ID: ENSDARG00000090454
  
Biological name :gnb1a
  
Synonyms : gnb1a / guanine nucleotide binding protein (G protein), beta polypeptide 1a / Q6PH57
  
Possible biological names infered from orthology : GNB1 / G protein subunit beta 1 / guanine nucleotide binding protein (G protein), beta 1 / P62873 / P62874
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 53269657
Gene end: 53334650
  
Corresponding Affymetrix probe sets: Dr.20008.3.A1_at (Zebrafish Array)   Dr.26493.1.A1_a_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000111963
Ensembl peptide - ENSDARP00000150406
NCBI entrez gene - 322104     See in Manteia.
swissprot - Q6PH57
ZFIN ID - ZDB-GENE-030131-823
Ensembl - ENSDARG00000090454
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GNB1ENSGALG00000001334Gallus gallus
 GNB1ENSG00000078369Homo sapiens
 Gnb1ENSMUSG00000029064Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*ENSDARG0000010437299
gnb2 / guanine nucleotide binding protein (G protein), beta polypeptide 2 / P62880* / P62879* / G protein subunit beta 2* / guanine nucleotide binding protein (G protein), beta 2*ENSDARG0000003535790
gnb4b / guanine nucleotide binding protein (G protein), beta polypeptide 4b / GNB4* / Q9HAV0* / G protein subunit beta 4*ENSDARG0000011538389
gnb3a / guanine nucleotide binding protein (G protein), beta polypeptide 3a / GNB3* / Q61011* / P16520* / G protein subunit beta 3* / guanine nucleotide binding protein (G protein), beta 3*ENSDARG0000000435874
gnb3b / guanine nucleotide binding protein (G protein), beta polypeptide 3b / GNB3* / Q61011* / P16520* / G protein subunit beta 3* / guanine nucleotide binding protein (G protein), beta 3*ENSDARG0000000269664
GNB4 / G protein subunit beta 4 / Q9HAV0*ENSDARG0000001927863
gnb5b / Q6PBY0 / guanine nucleotide binding protein (G protein), beta 5b / GNB5* / O14775* / P62881* / G protein subunit beta 5* / guanine nucleotide binding protein (G protein), beta 5*ENSDARG0000005537753
gnb5a / A1L271 / guanine nucleotide binding protein (G protein), beta 5a / GNB5* / P62881* / O14775* / G protein subunit beta 5* / guanine nucleotide binding protein (G protein), beta 5*ENSDARG0000009968552
wdr47a / WD repeat domain 47a / WDR47* / Q8CGF6* / O94967* / WD repeat domain 47*ENSDARG0000007813627
wdr47b / WD repeat domain 47b / WDR47* / O94967* / WD repeat domain 47*ENSDARG0000009975726


Protein motifs (from Interpro)
Interpro ID Name
 IPR001632  G-protein, beta subunit
 IPR001680  WD40 repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR016346  Guanine nucleotide-binding protein, beta subunit
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0048920 posterior lateral line neuromast primordium migration IGI
 biological_processGO:1902624 positive regulation of neutrophil migration IGI
 molecular_functionGO:0004871 obsolete signal transducer activity IEA


Pathways (from Reactome)
Pathway description
Activation of G protein gated Potassium channels
G-protein activation
Activation of the phototransduction cascade
Olfactory Signaling Pathway
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019418 kcnj2a / potassium inwardly-rectifying channel, subfamily J, member 2a / KCNJ2* / P63252* / P35561* / potassium voltage-gated channel subfamily J member 2* / potassium inwardly-rectifying c...  / complex
 ENSDARG00000024101 adra1d / adrenoceptor alpha 1D / P25100*  / complex / reaction
 ENSDARG00000011317 adra1ba / adrenoceptor alpha 1Ba / ADRA1B* / P35368* / adrenoceptor alpha 1B*  / complex / reaction
 ENSDARG00000016667 gabbr1b / gamma-aminobutyric acid (GABA) B receptor, 1b / GABBR1* / Q9UBS5* / Q9WV18* / gamma-aminobutyric acid type B receptor subunit 1*  / complex
 ENSDARG00000036058 gnao1b / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...  / complex
 ENSDARG00000035798 gngt1 / guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 / GNG11* / Q61012* / P61952* / P61953* / P63211* / G protein subunit gamma 11* / G protein s...  / complex / reaction
 ENSDARG00000002193 rho / P35359 / rhodopsin / P08100*  / complex / reaction
 ENSDARG00000025826 gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*  / complex / reaction
 ENSDARG00000028725 adra1aa / adrenoceptor alpha 1Aa / ADRA1A* / P35348* / adrenoceptor alpha 1A*  / complex / reaction
 ENSDARG00000044861 Q8AYN0 / opn1lw2 / opsin 1 (cone pigments), long-wave-sensitive, 2 / OPN1MW* / P04000* / P0DN77* / O35599* / P0DN78* / P04001* / OPN1LW* / OPN1MW3* / OPN1MW2* / opsin 1, long wave sensitive...  / complex / reaction
 ENSDARG00000058985 KCNJ6 / potassium voltage-gated channel subfamily J member 6 / P48051*  / complex
 ENSDARG00000044199 gnat1 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 / P20612* / P11488* / G protein subunit alpha transducin 1* / guanine nucleotide binding pro...  / complex
 ENSDARG00000042529 gnat2 / guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 / P50149* / P19087* / G protein subunit alpha transducin 2* / guanine nucleotide binding pro...  / complex
 ENSDARG00000060012 f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *  / complex / reaction
 ENSDARG00000040841 adra2a / adrenoceptor alpha 2A / P08913*  / complex / reaction
 ENSDARG00000043135 pomca / proopiomelanocortin a / POMC* / P01193* / P01189* / proopiomelanocortin* / pro-opiomelanocortin-alpha*  / complex / reaction
 ENSDARG00000039434 oprm1 / opioid receptor, mu 1 / P35372* / P42866*  / complex / reaction
 ENSDARG00000061042 gabbr2 / gamma-aminobutyric acid (GABA) B receptor, 2 / O75899* / Q80T41* / gamma-aminobutyric acid type B receptor subunit 2*  / complex
 ENSDARG00000062217 kcnj3b / potassium inwardly-rectifying channel, subfamily J, member 3b / KCNJ3* / P48549* / P63250* / potassium voltage-gated channel subfamily J member 3* / G protein-activated inward rect...  / complex
 ENSDARG00000044862 Q9W6A7 / opn1lw1 / opsin 1 (cone pigments), long-wave-sensitive, 1 / OPN1MW* / P04000* / P0DN77* / O35599* / P0DN78* / P04001* / OPN1LW* / OPN1MW3* / OPN1MW2* / opsin 1, long wave sensitive...  / complex / reaction
 ENSDARG00000058988 KCNJ15 / potassium voltage-gated channel subfamily J member 15 / Q99712*  / complex
 ENSDARG00000056831 gng2 / guanine nucleotide binding protein (G protein), gamma 2 / P59768* / P63213* / G protein subunit gamma 2*  / complex / reaction
 ENSDARG00000069669 adra2c / Q90WY6 / adrenoceptor alpha 2C / P18825* / Q01337* / Alpha-2C adrenergic receptor *  / complex / reaction
 ENSDARG00000069945 p2ry12 / purinergic receptor P2Y12 / Q9CPV9* / Q9H244* / purinergic receptor P2Y, G-protein coupled 12*  / complex / reaction
 ENSDARG00000070666 rhol / rhodopsin, like / RHO* / P15409* / P08100* / rhodopsin*  / complex / reaction
 ENSDARG00000068246 plcb3 / phospholipase C, beta 3 (phosphatidylinositol-specific) / P51432* / Q01970* / phospholipase C beta 3*  / complex / reaction
 ENSDARG00000077165 kcnj3a / potassium inwardly-rectifying channel, subfamily J, member 3a / KCNJ3* / P48549* / P63250* / potassium voltage-gated channel subfamily J member 3* / G protein-activated inward rect...  / complex
 ENSDARG00000090524 f2rl2 / coagulation factor II (thrombin) receptor-like 2 / O00254*  / complex / reaction
 ENSDARG00000069307 pomcb / proopiomelanocortin b / POMC* / P01193* / P01189* / proopiomelanocortin* / pro-opiomelanocortin-alpha*  / complex / reaction
 ENSDARG00000079472 CABZ01071020.1 / F2RL2* / O00254* / coagulation factor II thrombin receptor like 2*  / complex / reaction
 ENSDARG00000079399 F2RL3 / si:ch211-132p1.2 / O88634* / Q96RI0* / Proteinase-activated receptor 4 * / F2R like thrombin or trypsin receptor 3*  / complex / reaction
 ENSDARG00000090381 PLCB2 / phospholipase C beta 2 / A3KGF7* / Q00722* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 *  / complex / reaction
 ENSDARG00000013014 or101-1 / odorant receptor, family B, subfamily 101, member 1 / A6NND4* / OR2AT4* / Olfr521* / Olfr520* / olfactory receptor family 2 subfamily AT member 4*  / complex / reaction
 ENSDARG00000011487 gnaq / guanine nucleotide binding protein (G protein), q polypeptide / P50148* / P21279* / G protein subunit alpha q* / guanine nucleotide binding protein, alpha q polypeptide*  / complex / reaction
 ENSDARG00000030644 gnai3 / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 / GNAI1* / B2RSH2* / P08754* / P63096* / Q9DC51* / G protein subunit alpha i1* / G protein su...  / complex / reaction
 ENSDARG00000017294 gnai2b / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...  / complex / reaction
 ENSDARG00000073765 gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*  / complex / reaction
 ENSDARG00000018174 gnai2a / guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a / GNAI2* / P08752* / P04899* / G protein subunit alpha i2* / guanine nucleotide binding pro...  / complex / reaction
 ENSDARG00000090454 gnb1a / Q6PH57 / guanine nucleotide binding protein (G protein), beta polypeptide 1a / GNB1* / P62873* / G protein subunit beta 1*  / reaction
 ENSDARG00000087798 pdyn / prodynorphin / P01213*  / complex / reaction
 ENSDARG00000027638 adra1ab / adrenoceptor alpha 1Ab / ADRA1A* / P35348* / P97718* / adrenoceptor alpha 1A* / Alpha-1A adrenergic receptor *  / complex / reaction
 ENSDARG00000025013 gna14a / guanine nucleotide binding protein (G protein), alpha 14a / GNA14* / P30677* / O95837* / G protein subunit alpha 14* / guanine nucleotide binding protein, alpha 14*  / complex / reaction
 ENSDARG00000016364 gna15.1 / guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1 / GNA15* / P30679* / P30678* / G protein subunit alpha 15* / guanine nucleotide binding pro...  / complex / reaction
 ENSDARG00000009480 pdcl / phosducin-like / Q13371* / Q9DBX2* / Phosducin-like protein *  / complex
 ENSDARG00000038278 ptgir / prostaglandin I2 receptor / P43119* / P43252* / Prostacyclin receptor *  / complex
 ENSDARG00000104372 gnb1b / guanine nucleotide binding protein (G protein), beta polypeptide 1b / GNB1* / P62874* / P62873* / G protein subunit beta 1* / guanine nucleotide binding protein (G protein), beta 1*  / reaction
 ENSDARG00000061014 kcnj5 / potassium inwardly-rectifying channel, subfamily J, member 5 / P48544* / P48545* / potassium voltage-gated channel subfamily J member 5* / G protein-activated inward rectifier potas...  / complex
 ENSDARG00000016676 gnao1a / guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a / GNAO1* / P18872* / P09471* / G protein subunit alpha o1* / guanine nucleotide binding p...  / complex
 ENSDARG00000091140 pik3r6b / phosphoinositide-3-kinase, regulatory subunit 6b / PIK3R6* / Q5UE93* / Q3U6Q4* / phosphoinositide-3-kinase regulatory subunit 6*  / complex / reaction
 ENSDARG00000090815 kcnj10a / potassium inwardly-rectifying channel, subfamily J, member 10a / Q9JM63* / KCNJ10* / P78508* / ATP-sensitive inward rectifier potassium channel 10 * / potassium voltage-gated chan...  / complex
 ENSDARG00000105281 p2ry1 / purinergic receptor P2Y1 / P47900* / P49650* / purinergic receptor P2Y, G-protein coupled 1*  / complex
 ENSDARG00000102762 pik3r5 / phosphoinositide-3-kinase, regulatory subunit 5 / Q5SW28* / Q8WYR1*  / complex / reaction
 ENSDARG00000105022 FO704813.1 / KCNJ10* / P78508* / potassium voltage-gated channel subfamily J member 10*  / complex
 ENSDARG00000104965 kcnj12a / potassium inwardly-rectifying channel, subfamily J, member 12a / KCNJ18* / P52187* / Q14500* / B7U540* / KCNJ12* / ATP-sensitive inward rectifier potassium channel 12 * / potassiu...  / complex
 ENSDARG00000104389 kcnj2b / potassium inwardly-rectifying channel, subfamily J, member 2b / KCNJ2* / P63252* / P35561* / potassium voltage-gated channel subfamily J member 2* / potassium inwardly-rectifying c...  / complex
 ENSDARG00000099844 GNAZ / G protein subunit alpha z / P19086*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr