ENSDARG00000039215


Danio rerio

Features
Gene ID: ENSDARG00000039215
  
Biological name :arrb2a
  
Synonyms : arrb2a / arrestin, beta 2a
  
Possible biological names infered from orthology : ARRB2 / arrestin beta 2 / Beta-arrestin-2 / P32121 / Q91YI4
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 22890791
Gene end: 22907418
  
Corresponding Affymetrix probe sets: Dr.26320.1.A1_at (Zebrafish Array)   Dr.4114.1.S1_at (Zebrafish Array)   Dr.8781.2.A1_at (Zebrafish Array)   NM_214681_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000057290
Ensembl peptide - ENSDARP00000144541
NCBI entrez gene - 321378     See in Manteia.
RefSeq - NM_214681
RefSeq Peptide - NP_999846
swissprot - F1QLG1
swissprot - A0A286YBG8
ZFIN ID - ZDB-GENE-030131-29
Ensembl - ENSDARG00000039215
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARRB2ENSG00000141480Homo sapiens
 Arrb2ENSMUSG00000060216Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *ENSDARG0000001154589
arrb1 / arrestin, beta 1 / P49407*ENSDARG0000004324177
saga / S-antigen; retina and pineal gland (arrestin) a / SAG* / P20443* / P10523* / S-antigen visual arrestin* / S-antigen, retina and pineal gland (arrestin)*ENSDARG0000001261054
sagb / S-antigen; retina and pineal gland (arrestin) b / SAG* / P10523* / S-antigen visual arrestin*ENSDARG0000003837852
arr3a / arrestin 3a, retinal (X-arrestin) / ARR3* / Q9EQP6* / P36575* / arrestin 3* / Arrestin-C *ENSDARG0000005651147
arr3b / arrestin 3b, retinal (X-arrestin) / ARR3* / Q9EQP6* / P36575* / arrestin 3* / Arrestin-C *ENSDARG0000009847544


Protein motifs (from Interpro)
Interpro ID Name
 IPR000698  Arrestin
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014753  Arrestin, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR017864  Arrestin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001919 regulation of receptor recycling IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:1900136 regulation of chemokine activity IGI
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WNT5A-dependent internalization of FZD4
MAP2K and MAPK activation
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009288 primordial germ cell primordial germ cell mislocalised medially , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002790 Q6NWK2 / ap2m1a / ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000016163 usp33 / A5PMR2 / ubiquitin specific peptidase 33 / Q8R5K2* / Q8TEY7*  / complex
 ENSDARG00000035152 ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction
 ENSDARG00000007436 avpr2aa / arginine vasopressin receptor 2a, duplicate a / AVPR2* / O88721* / P30518* / arginine vasopressin receptor 2*  / complex / reaction
 ENSDARG00000026967 ap2s1 / adaptor-related protein complex 2, sigma 1 subunit / P53680* / P62743* / AP-2 complex subunit sigma *  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000002952 smo / smoothened, frizzled class receptor / P56726* / Q99835*  / complex
 ENSDARG00000060012 f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *  / complex / reaction
 ENSDARG00000033899 ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / reaction / complex
 ENSDARG00000087538 kif3a / kinesin family member 3A / P28741* / Q9Y496* / Kinesin-like protein KIF3A *  / complex
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000116374 chrm2b / cholinergic receptor, muscarinic 2b / CHRM2* / Q9ERZ4* / P08172* / cholinergic receptor muscarinic 2* / cholinergic receptor, muscarinic 2, cardiac*  / complex / reaction
 ENSDARG00000098612 chrm2a / cholinergic receptor, muscarinic 2a / CHRM2* / Q9ERZ4* / P08172* / cholinergic receptor muscarinic 2* / cholinergic receptor, muscarinic 2, cardiac*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr