ENSDARG00000026967


Danio rerio

Features
Gene ID: ENSDARG00000026967
  
Biological name :ap2s1
  
Synonyms : adaptor-related protein complex 2, sigma 1 subunit / ap2s1
  
Possible biological names infered from orthology : AP-2 complex subunit sigma / P53680 / P62743
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 8767650
Gene end: 8799977
  
Corresponding Affymetrix probe sets: Dr.26387.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000031559
NCBI entrez gene - 100148085     See in Manteia.
RefSeq - NM_213155
RefSeq Peptide - NP_998320
swissprot - Q6PEJ2
ZFIN ID - ZDB-GENE-040426-2174
Ensembl - ENSDARG00000026967
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AP2S1ENSG00000042753Homo sapiens
 Ap2s1ENSMUSG00000008036Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ap1s1 / adaptor-related protein complex 1, sigma 1 subunit / P61966* / P61967* / AP-1 complex subunit sigma-1A *ENSDARG0000005680348
ap1s2 / adaptor-related protein complex 1, sigma 2 subunitENSDARG0000005850447
ap1s3a / adaptor-related protein complex 1, sigma 3 subunit, a / AP1S3* / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*ENSDARG0000011043945
ap1s3b / adaptor-related protein complex 1, sigma 3 subunit, b / AP1S3* / Q96PC3* / Q7TN05* / AP-1 complex subunit sigma-3 * / adaptor related protein complex 1 sigma 3 subunit*ENSDARG0000002796642
ap4s1 / adaptor-related protein complex 4, sigma 1 subunit / Q9WVL1* / Q9Y587* / AP-4 complex subunit sigma-1 *ENSDARG0000005422040
CABZ01102528.1ENSDARG0000009899030
AP1S2 / adaptor related protein complex 1 sigma 2 subunit / P56377*ENSDARG0000011322517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000804  Clathrin adaptor complex, small chain
 IPR011012  Longin-like domain superfamily
 IPR016635  Adaptor protein complex, sigma subunit
 IPR022775  AP complex, mu/sigma subunit
 IPR027156  AP-2 complex subunit sigma


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030122 AP-2 adaptor complex IEA
 molecular_functionGO:0008565 protein transporter activity IEA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling
MHC class II antigen presentation
Trafficking of GluR2-containing AMPA receptors
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002790 Q6NWK2 / ap2m1a / ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000006257 vldlr / very low density lipoprotein receptor / P98155* / P98156*  / complex / reaction
 ENSDARG00000035152 ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction
 ENSDARG00000004586 ntrk1 / neurotrophic tyrosine kinase, receptor, type 1 / P04629* / Q3UFB7* / neurotrophic receptor tyrosine kinase 1* / High affinity nerve growth factor receptor *  / complex
 ENSDARG00000037498 gria3b / glutamate receptor, ionotropic, AMPA 3b / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...  / reaction
 ENSDARG00000032737 gria3a / glutamate receptor, ionotropic, AMPA 3a / GRIA3* / P42263* / Q9Z2W9* / glutamate ionotropic receptor AMPA type subunit 3* / Mus musculus glutamate receptor, ionotropic, AMPA3 (alph...  / reaction
 ENSDARG00000009087 cd74a / CD74 molecule, major histocompatibility complex, class II invariant chain a / CD74* / P04233* / P04441* / CD74 molecule* / CD74 antigen (invariant polypeptide of major histocompatib...  / complex / reaction
 ENSDARG00000026967 ap2s1 / adaptor-related protein complex 2, sigma 1 subunit / P53680* / P62743* / AP-2 complex subunit sigma *  / complex / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction / complex
 ENSDARG00000011545 arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction
 ENSDARG00000045618 clta / clathrin, light chain A / P09496*  / complex / reaction
 ENSDARG00000043510 vamp4 / vesicle-associated membrane protein 4 / O70480* / O75379*  / complex / reaction
 ENSDARG00000039215 arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *  / complex / reaction
 ENSDARG00000033899 ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / complex / reaction
 ENSDARG00000015053 grip1 / glutamate receptor interacting protein 1 / Q925T6* / Q9Y3R0*  / reaction
 ENSDARG00000032714 gria1b / glutamate receptor, ionotropic, AMPA 1b / GRIA1* / P23818* / P42261* / Glutamate receptor 1 * / glutamate ionotropic receptor AMPA type subunit 1*  / reaction
 ENSDARG00000023600 sh3gl2a / SH3 domain containing GRB2 like 2a, endophilin A1 / Q99962* / SH3GL2* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSDARG00000014050 ngfb / Q6YBR5 / nerve growth factor b (beta polypeptide) / NGF* / P01138* / P01139* / nerve growth factor* / Beta-nerve growth factor *  / complex
 ENSDARG00000074185 pcsk9 / proprotein convertase subtilisin/kexin type 9 / Q8NBP7*  / complex / reaction
 ENSDARG00000058961 ngfa / O73797 / nerve growth factor a (beta polypeptide) / NGF* / P01139* / P01138* / nerve growth factor* / Beta-nerve growth factor *  / complex
 ENSDARG00000031116 dnal4a / dynein, axonemal, light chain 4a / DNAL4* / Q9DCM4* / O96015* / dynein axonemal light chain 4* / Dynein light chain 4, axonemal *  / reaction
 ENSDARG00000088841 dnal4b / dynein, axonemal, light chain 4b / DNAL4* / Q9DCM4* / O96015* / dynein axonemal light chain 4* / Dynein light chain 4, axonemal *  / reaction
 ENSDARG00000052368 cltb / clathrin, light chain B / P09497* / Q6IRU5*  / complex / reaction






 

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