ENSDARG00000006257


Danio rerio

Features
Gene ID: ENSDARG00000006257
  
Biological name :vldlr
  
Synonyms : very low density lipoprotein receptor / vldlr
  
Possible biological names infered from orthology : P98155 / P98156
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 15255012
Gene end: 15305767
  
Corresponding Affymetrix probe sets: Dr.25952.1.A1_s_at (Zebrafish Array)   Dr.25952.1.A1_x_at (Zebrafish Array)   Dr.4561.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000121485
Ensembl peptide - ENSDARP00000154890
Ensembl peptide - ENSDARP00000153068
Ensembl peptide - ENSDARP00000134555
Ensembl peptide - ENSDARP00000020206
NCBI entrez gene - 393897     See in Manteia.
RefSeq - XM_005155563
RefSeq - XM_005155564
RefSeq - NM_200923
RefSeq Peptide - NP_957217
swissprot - E9QBA5
swissprot - E7FF13
swissprot - A0A0R4IGN2
ZFIN ID - ZDB-GENE-040426-803
Ensembl - ENSDARG00000006257
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 VLDLRENSGALG00000010166Gallus gallus
 VLDLRENSG00000147852Homo sapiens
 VldlrENSMUSG00000024924Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lrp8 / low density lipoprotein receptor-related protein 8, apolipoprotein e receptor / Q14114* / Q924X6* / LDL receptor related protein 8* / Low-density lipoprotein receptor-related protein 8 *ENSDARG0000007007453
ldlra / low density lipoprotein receptor a / LDLR* / P35951* / P01130* / low density lipoprotein receptor*ENSDARG0000002947644
ldlrb / low density lipoprotein receptor b / LDLR* / P35951* / P01130* / low density lipoprotein receptor*ENSDARG0000002675939
lrp1ab / low density lipoprotein receptor-related protein 1Ab / LRP1* / Q07954* / LDL receptor related protein 1*ENSDARG0000002914636
lrp2b / low density lipoprotein receptor-related protein 2bENSDARG0000000790635
lrp1bb / low density lipoprotein receptor-related protein 1Bb / LRP1B* / Q9NZR2* / LDL receptor related protein 1B*ENSDARG0000006151735
lrp1aa / low density lipoprotein receptor-related protein 1Aa / LRP1* / Q07954* / LDL receptor related protein 1*ENSDARG0000009782735
lrp2a / low density lipoprotein receptor-related protein 2a / LRP2* / P98164* / A2ARV4* / LDL receptor related protein 2* / low density lipoprotein receptor-related protein 2*ENSDARG0000010250635
lrp1ba / low density lipoprotein receptor-related protein 1Ba / LRP1B* / Q9NZR2* / LDL receptor related protein 1B*ENSDARG0000000478933
lrp13 / low-density lipoprotein receptor related-protein 13 / Gm19410*ENSDARG0000002347928
si:dkey-88l16.3 / Gm19410*ENSDARG0000009405527
lrp5 / low density lipoprotein receptor-related protein 5 / O75197* / LDL receptor related protein 5*ENSDARG0000000692117
lrp6 / low density lipoprotein receptor-related protein 6 / O75581* / LDL receptor related protein 6*ENSDARG000001001432
CABZ01071171.1 / Danio rerio low density lipoprotein receptor-related protein 4 (lrp4), mRNA. / LRP4* / Q8VI56* / O75096* / LDL receptor related protein 4* / Low-density lipoprotein recepto...ENSDARG000001163532
lrp1ba / low density lipoprotein receptor-related protein 1Ba / Gm19410*ENSDARG000000941711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR018097  EGF-like calcium-binding, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR032931  Very low-density lipoprotein receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0030229 very-low-density lipoprotein particle receptor activity IEA


Pathways (from Reactome)
Pathway description
Reelin signalling pathway
VLDLR internalisation and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002790 Q6NWK2 / ap2m1a / ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000035152 ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction
 ENSDARG00000026967 ap2s1 / adaptor-related protein complex 2, sigma 1 subunit / P53680* / P62743* / AP-2 complex subunit sigma *  / complex / reaction
 ENSDARG00000045618 clta / clathrin, light chain A / P09496*  / complex / reaction
 ENSDARG00000074185 pcsk9 / proprotein convertase subtilisin/kexin type 9 / Q8NBP7*  / complex / reaction
 ENSDARG00000033899 ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000075853 sh3kbp1 / SH3-domain kinase binding protein 1 / Q8R550* / Q96B97* / SH3 domain containing kinase binding protein 1*  / complex
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / complex / reaction
 ENSDARG00000008859 mylipa / Q6TEM9 / myosin regulatory light chain interacting protein a / MYLIP* / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP * / myosin regulatory light chain interacting protein*  / reaction
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction






 

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