ENSDARG00000074185


Danio rerio

Features
Gene ID: ENSDARG00000074185
  
Biological name :pcsk9
  
Synonyms : pcsk9 / proprotein convertase subtilisin/kexin type 9
  
Possible biological names infered from orthology : Q80W65 / Q8NBP7
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 7398090
Gene end: 7432867
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000104114
NCBI entrez gene - 100150316     See in Manteia.
swissprot - E7F2J6
ZFIN ID - ZDB-GENE-060927-1
Ensembl - ENSDARG00000074185
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PCSK9ENSG00000169174Homo sapiens
 Pcsk9ENSMUSG00000044254Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR010259  Peptidase S8 propeptide/proteinase inhibitor I9
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR034193  Proteinase K-like catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0022008 neurogenesis IMP
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
VLDLR internalisation and degradation
Post-translational protein phosphorylation
LDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain structure , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary absent , abnormal
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 ZFA:0000445 optic tectum optic tectum absent , abnormal
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 ZFA:0001094 whole organism whole organism dead , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000006257 vldlr / very low density lipoprotein receptor / P98155* / P98156*  / complex / reaction
 ENSDARG00000002790 Q6NWK2 / ap2m1a / ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000035152 ap2b1 / adaptor-related protein complex 2, beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex / reaction
 ENSDARG00000026967 ap2s1 / adaptor-related protein complex 2, sigma 1 subunit / P53680* / P62743* / AP-2 complex subunit sigma *  / complex / reaction
 ENSDARG00000045618 clta / clathrin, light chain A / P09496*  / complex / reaction
 ENSDARG00000033899 ap2m1b / adaptor-related protein complex 2, mu 1 subunit, b / AP2M1* / Q96CW1* / P84091* / AP-2 complex subunit mu * / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSDARG00000090716 cltcb / clathrin, heavy chain b (Hc) / CLTC* / Q00610* / clathrin heavy chain*  / complex / reaction






 

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