ENSDARG00000043241


Danio rerio

Features
Gene ID: ENSDARG00000043241
  
Biological name :arrb1
  
Synonyms : arrb1 / arrestin, beta 1
  
Possible biological names infered from orthology : Beta-arrestin-1 / P49407 / Q8BWG8
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 5390734
Gene end: 5467477
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000105997
NCBI entrez gene - 553266     See in Manteia.
RefSeq - NM_001159822
RefSeq Peptide - NP_001153294
swissprot - C3PTE8
ZFIN ID - ZDB-GENE-060824-1
Ensembl - ENSDARG00000043241
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARRB1ENSG00000137486Homo sapiens
 Arrb1ENSMUSG00000018909Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arrb2b / arrestin, beta 2b / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *ENSDARG0000001154575
arrb2a / arrestin, beta 2a / ARRB2* / Q91YI4* / P32121* / arrestin beta 2* / Beta-arrestin-2 *ENSDARG0000003921575
saga / S-antigen; retina and pineal gland (arrestin) a / SAG* / P20443* / P10523* / S-antigen visual arrestin* / S-antigen, retina and pineal gland (arrestin)*ENSDARG0000001261052
sagb / S-antigen; retina and pineal gland (arrestin) b / SAG* / P10523* / S-antigen visual arrestin*ENSDARG0000003837850
arr3a / arrestin 3a, retinal (X-arrestin) / ARR3* / Q9EQP6* / P36575* / arrestin 3* / Arrestin-C *ENSDARG0000005651150
arr3b / arrestin 3b, retinal (X-arrestin) / ARR3* / Q9EQP6* / P36575* / arrestin 3* / Arrestin-C *ENSDARG0000009847546


Protein motifs (from Interpro)
Interpro ID Name
 IPR000698  Arrestin
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014753  Arrestin, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR017864  Arrestin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001919 regulation of receptor recycling IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0045746 negative regulation of Notch signaling pathway IMP
 biological_processGO:0048368 lateral mesoderm development IMP
 biological_processGO:0098508 endothelial to hematopoietic transition IMP
 biological_processGO:1900136 regulation of chemokine activity IGI
 biological_processGO:1903978 regulation of microglial cell activation IMP
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Thrombin signalling through proteinase activated receptors (PARs)
MAP2K and MAPK activation
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
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 ZFA:0000114 heart heart increased size , abnormal
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 ZFA:0000445 optic tectum optic tectum microglial cell morphology , abnormal
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 ZFA:0001058 caudal fin caudal fin curled , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism necrotic , abnormal
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 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta increased amount , abnormal
ventral wall of dorsal aorta decreased amount , abnormal
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 ZFA:0009077 microglial cell microglial cell cell projection increased amount , abnormal
microglial cell cell body increased size , abnormal
microglial cell cell body increased volume , abnormal
microglial cell phagocytosis increased frequency , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
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 ZFA:0009288 primordial germ cell primordial germ cell mislocalised medially , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000007436 avpr2aa / arginine vasopressin receptor 2a, duplicate a / AVPR2* / O88721* / P30518* / arginine vasopressin receptor 2*  / complex / reaction
 ENSDARG00000060012 f2r / coagulation factor II (thrombin) receptor / P25116* / P30558* / Proteinase-activated receptor 1 *  / complex / reaction
 ENSDARG00000087538 kif3a / kinesin family member 3A / P28741* / Q9Y496* / Kinesin-like protein KIF3A *  / complex
 ENSDARG00000002952 smo / smoothened, frizzled class receptor / P56726* / Q99835*  / complex
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000070573 mapk3 / mitogen-activated protein kinase 3 / P27361* / Q63844*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex / reaction
 ENSDARG00000116374 chrm2b / cholinergic receptor, muscarinic 2b / CHRM2* / Q9ERZ4* / P08172* / cholinergic receptor muscarinic 2* / cholinergic receptor, muscarinic 2, cardiac*  / complex / reaction
 ENSDARG00000098612 chrm2a / cholinergic receptor, muscarinic 2a / CHRM2* / Q9ERZ4* / P08172* / cholinergic receptor muscarinic 2* / cholinergic receptor, muscarinic 2, cardiac*  / complex / reaction






 

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