ENSDARG00000056587


Danio rerio

Features
Gene ID: ENSDARG00000056587
  
Biological name :cyp2r1
  
Synonyms : cyp2r1 / cytochrome P450, family 2, subfamily R, polypeptide 1
  
Possible biological names infered from orthology : cytochrome P450 family 2 subfamily R member 1 / Q6VVW9 / Q6VVX0 / Vitamin D 25-hydroxylase
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 27455321
Gene end: 27697234
  
Corresponding Affymetrix probe sets: Dr.19059.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000073546
Ensembl peptide - ENSDARP00000123917
Ensembl peptide - ENSDARP00000125033
NCBI entrez gene - 563369     See in Manteia.
swissprot - F6P2A1
swissprot - F8W4J4
swissprot - F8W5N4
ZFIN ID - ZDB-GENE-110114-1
Ensembl - ENSDARG00000056587
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP2R1ENSGALG00000006050Gallus gallus
 CYP2R1ENSG00000186104Homo sapiens
 Cyp2r1ENSMUSG00000030670Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cyp2p7 / cyp2p9 / cytochrome P450, family 2, subfamily P, polypeptide 7 / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54749* / O54750* / CYP2J2* / Cyp2j5* / Cyp2j6* / Cyp2j11* / Cyp2j12* / Cyp...ENSDARG0000004298042
cyp2p8 / cytochrome P450, family 2, subfamily P, polypeptide 8 / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54749* / O54750* / CYP2J2* / Cyp2j5* / Cyp2j11* / Cyp2j12* / Cyp2j13* / C...ENSDARG0000004298242
cyp2p9 / cytochrome P450, family 2, subfamily P, polypeptide 9 / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54749* / O54750* / CYP2J2* / Cyp2j5* / Cyp2j11* / Cyp2j12* / Cyp2j13* / C...ENSDARG0000002263141
cyp2p6 / cytochrome P450, family 2, subfamily P, polypeptide 6 / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54749* / O54750* / CYP2J2* / Cyp2j5* / Cyp2j11* / Cyp2j12* / Cyp2j13* / C...ENSDARG0000004297841
cyp2p10 / cytochrome P450, family 2, subfamily P, polypeptide 10 / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54749* / O54750* / CYP2J2* / Cyp2j5* / Cyp2j11* / Cyp2j12* / Cyp2j13* /...ENSDARG0000004299041
cyp2j20 / cytochrome P450, family 2, subfamily J, polypeptide 20 / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54749* / O54750* / CYP2J2* / Cyp2j5* / Cyp2j11* / Cyp2j12* / Cyp2j13* /...ENSDARG0000009405741
cyp2ae1 / cytochrome P450, family 2, subfamily AE, polypeptide 1 / CYP2J2* / O54749* / Cyp2j5* / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54750* / Cyp2j13* / Cyp2j12* / Cyp2j11* /...ENSDARG0000001352440
cyp2v1 / cytochrome P450, family 2, subfamily V, polypeptide 1 / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54749* / O54750* / CYP2J2* / Cyp2j5* / Cyp2j11* / Cyp2j12* / Cyp2j13* / C...ENSDARG0000001848540
cyp2ad3 / cytochrome P450, family 2, subfamily AD, polypeptide 3 / CYP2J2* / O54749* / Cyp2j5* / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54750* / Cyp2j13* / Cyp2j12* / Cyp2j11* /...ENSDARG0000002265040
cyp2ad2 / cytochrome P450, family 2, subfamily AD, polypeptide 2 / CYP2J2* / O54749* / Cyp2j5* / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54750* / Cyp2j13* / Cyp2j12* / Cyp2j11* /...ENSDARG0000002117239
cyp2n13 / cytochrome P450, family 2, subfamily N, polypeptide 13 / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54749* / O54750* / CYP2J2* / Cyp2j5* / Cyp2j11* / Cyp2j12* / Cyp2j13* /...ENSDARG0000004295338
cyp2ad6 / cytochrome P450, family 2, subfamily AD, polypeptide 6 / CYP2J2* / O54749* / Cyp2j5* / Cyp2j6* / Cyp2j7* / Cyp2j8* / Cyp2j9* / P51589* / O54750* / Cyp2j13* / Cyp2j12* / Cyp2j11* /...ENSDARG0000004295638
cyp2k20 / cytochrome P450, family 2, subfamily k, polypeptide 20 / Q8TAV3* / CYP2W1* / E9Q816* / Cytochrome P450 2W1 * / cytochrome P450 family 2 subfamily W member 1*ENSDARG0000010163238
cyp2k20 / cyp2k21 / cytochrome P450, family 2, subfamily k, polypeptide 21 / E9Q816* / CYP2W1* / Q8TAV3* / Cytochrome P450 2W1 * / cytochrome P450 family 2 subfamily W member 1*ENSDARG0000010515138
cyp2u1 / cytochrome P450, family 2, subfamily U, polypeptide 1 / Q7Z449* / Q9CX98* / Cytochrome P450 2U1 * / cytochrome P450 family 2 subfamily U member 1*ENSDARG0000002654837
FO904880.1 / CYP2J2* / P51589* / cytochrome P450 family 2 subfamily J member 2*ENSDARG0000011036637
cyp2k16 / cytochrome P450, family 2, subfamily K, polypeptide16 / Q8TAV3* / CYP2W1* / E9Q816* / Cytochrome P450 2W1 * / cytochrome P450 family 2 subfamily W member 1*ENSDARG0000010298136
cyp2k17 / cytochrome P450, family 2, subfamily K, polypeptide17 / Q8TAV3* / CYP2W1* / E9Q816* / Cytochrome P450 2W1 * / cytochrome P450 family 2 subfamily W member 1*ENSDARG0000010452936
cyp2k8 / cytochrome P450, family 2, subfamily K, polypeptide 8 / Q8TAV3* / CYP2W1* / E9Q816* / Cytochrome P450 2W1 * / cytochrome P450 family 2 subfamily W member 1*ENSDARG0000010119035
cyp2k22 / cytochrome P450, family 2, subfamily K, polypeptide 22 / Q8TAV3* / CYP2W1* / E9Q816* / Cytochrome P450 2W1 * / cytochrome P450 family 2 subfamily W member 1*ENSDARG0000004043334


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0071305 cellular response to vitamin D IMP
 biological_processGO:0071425 hematopoietic stem cell proliferation IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008395 steroid hydroxylase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Vitamin D (calciferol) metabolism
Vitamins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000118 hypophysis hypophysis increased amount , abnormal
Show

 ZFA:0000123 liver liver increased amount , abnormal
liver decreased amount , abnormal
liver D3 vitamins decreased amount , abnormal
Show

 ZFA:0000242 male organism male organism lipid increased amount , abnormal
Show

 ZFA:0000303 female organism female organism lipid increased amount , abnormal
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 ZFA:0001094 whole organism whole organism length , ameliorated
whole organism weight , ameliorated
whole organism decreased length , abnormal
whole organism decreased weight , abnormal
whole organism decreased size , abnormal
whole organism lipid amount , ameliorated
whole organism lipid increased amount , abnormal
Show

 ZFA:0001656 pleuroperitoneal cavity pleuroperitoneal cavity fat cell increased amount , abnormal
Show

 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta decreased amount , abnormal
Show

 ZFA:0005345 adipose tissue adipose tissue increased amount , abnormal
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 ZFA:0005654 blood plasma blood plasma fatty acid increased amount , abnormal
blood plasma D3 vitamins decreased amount , abnormal
Show

 ZFA:0005759 visceral fat visceral fat amount , ameliorated
visceral fat increased amount , abnormal
visceral fat decreased amount , abnormal
visceral fat D3 vitamins decreased amount , abnormal
visceral fat mitochondrion membrane potential , abnormal
visceral fat mitochondrion decreased functionality , abnormal
visceral fat mitochondrion decreased amount , abnormal
Show

 ZFA:0005762 subcutaneous fat subcutaneous fat increased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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