ENSDARG00000056648


Danio rerio

Features
Gene ID: ENSDARG00000056648
  
Biological name :ext2
  
Synonyms : exostosin glycosyltransferase 2 / ext2
  
Possible biological names infered from orthology : Mus musculus exostoses (multiple) 2 (Ext2), transcript variant 1, mRNA. / P70428 / Q93063
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 26844261
Gene end: 26892613
  
Corresponding Affymetrix probe sets: Dr.6710.1.A1_at (Zebrafish Array)   NM_001008400_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000073621
NCBI entrez gene - 493780     See in Manteia.
RefSeq - NM_001008400
RefSeq Peptide - NP_001008400
swissprot - F1QUC2
ZFIN ID - ZDB-GENE-041124-3
Ensembl - ENSDARG00000056648
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EXT2ENSGALG00000031542Gallus gallus
 EXT2ENSG00000151348Homo sapiens
 Ext2ENSMUSG00000027198Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ext1a / Q5IGR8 / exostosin glycosyltransferase 1a / EXT1* / P97464* / Q16394* / Exostosin-1 * / exostosin glycosyltransferase 1*ENSDARG0000010315535
extl3 / exostosin-like glycosyltransferase 3 / O43909*ENSDARG0000002681134
ext1b / exostosin glycosyltransferase 1b / EXT1* / Q16394* / exostosin glycosyltransferase 1*ENSDARG0000010101934
extl2 / exostosin-like glycosyltransferase 2 / Q9ES89* / Q9UBQ6* / Exostosin-like 2 *ENSDARG0000006319113
ext1c / exostoses (multiple) 1c / EXTL1* / Q92935* / Q9JKV7* / Exostosin-like 1 * / exostosin like glycosyltransferase 1*ENSDARG0000003564910


Protein motifs (from Interpro)
Interpro ID Name
 IPR004263  Exostosin-like
 IPR015338  Exostosin , C-terminal
 IPR027673  Exostosin-2
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001503 ossification IMP
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0006024 glycosaminoglycan biosynthetic process IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0030166 proteoglycan biosynthetic process IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030516 regulation of axon extension IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0033339 pectoral fin development IMP
 biological_processGO:0035118 embryonic pectoral fin morphogenesis IMP
 biological_processGO:0035138 pectoral fin morphogenesis IMP
 biological_processGO:0042476 odontogenesis IMP
 biological_processGO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048920 posterior lateral line neuromast primordium migration IMP
 biological_processGO:0050650 chondroitin sulfate proteoglycan biosynthetic process IGI
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0097374 sensory neuron axon guidance IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015020 glucuronosyltransferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity ISS


Pathways (from Reactome)
Pathway description
HS-GAG biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000048 olfactory placode olfactory placode hypoplastic , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000085 apical ectodermal ridge pectoral fin bud apical ectodermal ridge pectoral fin bud aplastic , abnormal
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 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
pharyngeal arch 3-7 skeleton decreased size , abnormal
pharyngeal arch 3-7 skeleton decreased length , abnormal
pharyngeal arch 3-7 skeleton increased thickness , abnormal
pharyngeal arch 3-7 skeleton increased width , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000108 fin fin decreased size , abnormal
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 ZFA:0000109 forebrain forebrain decreased size , abnormal
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 ZFA:0000114 heart heart anatomical region has extra parts of type muscle , abnormal
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 ZFA:0000141 pectoral fin bud pectoral fin bud hypoplastic , abnormal
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 ZFA:0000184 cleithrum cleithrum decreased size , abnormal
cleithrum malformed , abnormal
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 ZFA:0000217 inner ear inner ear quality , abnormal
inner ear structure , abnormal
inner ear increased size , abnormal
inner ear morphology , abnormal
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 ZFA:0000243 neuromast neuromast decreased distance neuromast , abnormal
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 ZFA:0000250 opercle opercle decreased size , abnormal
opercle malformed , abnormal
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 ZFA:0000252 optic tract optic tract structure , abnormal
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 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000292 surface structure surface structure quality , abnormal
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 ZFA:0000384 levator arcus palatini levator arcus palatini increased width , abnormal
levator arcus palatini shortened , abnormal
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 ZFA:0000396 nervous system nervous system quality , abnormal
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 ZFA:0000407 pectoral girdle pectoral girdle decreased size , abnormal
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 ZFA:0000465 adductor operculi adductor operculi increased width , abnormal
adductor operculi shortened , abnormal
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 ZFA:0000498 dilator operculi dilator operculi increased width , abnormal
dilator operculi shortened , abnormal
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 ZFA:0000547 mouth mouth quality , abnormal
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 ZFA:0000655 dorsomedial optic tract dorsomedial optic tract composition , abnormal
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 ZFA:0000694 ceratobranchial 5 tooth ceratobranchial 5 tooth increased distance ceratobranchial 5 tooth , abnormal
ceratobranchial 5 tooth decreased concentration enameloid , abnormal
ceratobranchial 5 tooth distal surface split , abnormal
ceratobranchial 5 tooth ossified , abnormal
ceratobranchial 5 tooth decreased length , abnormal
ceratobranchial 5 tooth increased thickness , abnormal
ceratobranchial 5 tooth increased width , abnormal
ceratobranchial 5 tooth mislocalised posteriorly , abnormal
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 ZFA:0000715 adductor hyohyoid adductor hyohyoid increased width , abnormal
adductor hyohyoid shortened , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast shape , abnormal
posterior lateral line neuromast elongated , abnormal
posterior lateral line neuromast hair cell dead , abnormal
posterior lateral line neuromast has extra parts of type neuromast cell projection, abnormal
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 ZFA:0001078 thymus thymus decreased volume , abnormal
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 ZFA:0001089 myoseptum myoseptum anatomical region increased distribution , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism dead , abnormal
whole organism anterior-posterior axis decreased length , abnormal
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 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
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 ZFA:0001137 ventral tooth row ventral tooth row has extra parts of type ceratobranchial 5 tooth , abnormal
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 ZFA:0001140 dorsal tooth row dorsal tooth row has fewer parts of type ceratobranchial 5 tooth , abnormal
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 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium morphology , abnormal
posterior lateral line primordium has extra parts of type posterior lateral line primordium filopodium, abnormal
posterior lateral line primordium decreased distribution , abnormal
posterior lateral line primordium anatomical region decreased distribution , abnormal
posterior lateral line primordium membrane decreased distribution , abnormal
posterior lateral line primordium increased size , abnormal
posterior lateral line primordium increased distribution , abnormal
posterior lateral line primordium anatomical region increased distribution , abnormal
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 ZFA:0001161 pectoral fin pectoral fin quality , abnormal
pectoral fin decreased size , abnormal
pectoral fin absent , abnormal
pectoral fin aplastic , abnormal
pectoral fin decreased length , abnormal
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 ZFA:0001174 pharyngeal epithelium pharyngeal epithelium decreased thickness , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage increased size , abnormal
Meckels cartilage decreased length , abnormal
Meckels cartilage anterior side decreased distance ceratohyal cartilage posterior side, abnormal
Meckels cartilage sloped downward , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
mandibular arch skeleton decreased size , abnormal
mandibular arch skeleton decreased length , abnormal
mandibular arch skeleton increased thickness , abnormal
mandibular arch skeleton condensed , abnormal
mandibular arch skeleton increased width , abnormal
mandibular arch skeleton mislocalised posteriorly , abnormal
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 ZFA:0001239 ceratobranchial 5 bone ceratobranchial 5 bone malformed , abnormal
ceratobranchial 5 bone ossified , abnormal
ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth , abnormal
ceratobranchial 5 bone decreased length , abnormal
ceratobranchial 5 bone apoptotic , abnormal
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 ZFA:0001276 pharyngeal arch 2 skeleton pharyngeal arch 2 skeleton decreased size , abnormal
pharyngeal arch 2 skeleton decreased length , abnormal
pharyngeal arch 2 skeleton increased thickness , abnormal
pharyngeal arch 2 skeleton increased width , abnormal
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 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage chondrocyte disorganized , abnormal
ceratohyal cartilage decreased length , abnormal
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 ZFA:0001456 pectoral fin endoskeletal disc pectoral fin endoskeletal disc absent , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage deformed , abnormal
cranial cartilage extracellular matrix composition , abnormal
cranial cartilage extracellular matrix component spatial pattern , abnormal
cranial cartilage shape , abnormal
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 ZFA:0001460 pharyngeal arch cartilage pharyngeal arch cartilage chondrocyte circular , abnormal
pharyngeal arch cartilage chondrocyte disorganized , abnormal
pharyngeal arch cartilage decreased length , abnormal
pharyngeal arch cartilage increased thickness , abnormal
pharyngeal arch cartilage oriented , abnormal
pharyngeal arch cartilage chondrocyte crowded , abnormal
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 ZFA:0001501 cartilage element cartilage element decreased length , abnormal
cartilage element increased thickness , abnormal
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 ZFA:0001519 ceratobranchial 4 cartilage ceratobranchial 4 cartilage decreased size , abnormal
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 ZFA:0001580 neurocranium neurocranium decreased length , abnormal
neurocranium increased thickness , abnormal
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 ZFA:0001590 dermal bone dermal bone hypoplastic , abnormal
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 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 decreased length , abnormal
pharyngeal arch 3-7 decreased size , abnormal
pharyngeal arch 3-7 increased width , abnormal
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 ZFA:0001651 sternohyoid sternohyoid increased width , abnormal
sternohyoid shortened , abnormal
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 ZFA:0001652 head muscle head muscle increased width , abnormal
head muscle shortened , abnormal
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 ZFA:0005316 fin fold pectoral fin bud fin fold pectoral fin bud absent , abnormal
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 ZFA:0005317 pectoral fin fold pectoral fin fold aplastic , abnormal
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 ZFA:0007008 ventral intermandibularis anterior ventral intermandibularis anterior increased width , abnormal
ventral intermandibularis anterior shortened , abnormal
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 ZFA:0007048 ventral intermandibularis posterior ventral intermandibularis posterior increased width , abnormal
ventral intermandibularis posterior shortened , abnormal
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 ZFA:0007049 adductor mandibulae adductor mandibulae increased width , abnormal
adductor mandibulae shortened , abnormal
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 ZFA:0007051 interhyoideus interhyoideus increased width , abnormal
interhyoideus shortened , abnormal
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 ZFA:0007052 hyohyoideus hyohyoideus absent , abnormal
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 ZFA:0009084 chondrocyte chondrocyte morphology , abnormal
chondrocyte circular , abnormal
chondrocyte fibrillar collagen trimer absent , abnormal
chondrocyte extracellular matrix condensed , abnormal
chondrocyte extracellular matrix decreased area , abnormal
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 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron axon mislocalized adaxially , abnormal
Rohon-Beard neuron axon subdermal , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon irregular spatial pattern , abnormal
retinal ganglion cell axon misrouted , abnormal
retinal ganglion cell axon branched , abnormal
retinal ganglion cell axon fasciculation , abnormal
retinal ganglion cell axon displaced , abnormal
retinal ganglion cell axon organization quality , abnormal
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 ZFA:0009365 interneuromast cell interneuromast cell has extra parts of type interneuromast cell cell projection, abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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