ENSDARG00000057577


Danio rerio

Features
Gene ID: ENSDARG00000057577
  
Biological name :mbtps2
  
Synonyms : mbtps2 / membrane-bound transcription factor peptidase, site 2
  
Possible biological names infered from orthology : Membrane-bound transcription factor site-2 protease / O43462 / Q3TTC2 / Q8CHX6
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 25447911
Gene end: 25461267
  
Corresponding Affymetrix probe sets: Dr.20573.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000096598
swissprot - F1R4A6
ZFIN ID - ZDB-GENE-030131-6598
Ensembl - ENSDARG00000057577
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MBTPS2ENSGALG00000016382Gallus gallus
 MBTPS2ENSG00000012174Homo sapiens
 Mbtps2ENSMUSG00000046873Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001193  Membrane-bound transcription factor site-2 protease
 IPR001478  PDZ domain
 IPR008915  Peptidase M50


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0036500 ATF6-mediated unfolded protein response IBA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IBA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)
ATF6 (ATF6-alpha) activates chaperones
CREB3 factors activate genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 chondrocyte disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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