ENSGALG00000016382


Gallus gallus

Features
Gene ID: ENSGALG00000016382
  
Biological name :MBTPS2
  
Synonyms : MBTPS2 / membrane bound transcription factor peptidase, site 2
  
Possible biological names infered from orthology : Membrane-bound transcription factor site-2 protease / O43462 / Q3TTC2 / Q8CHX6
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 119066345
Gene end: 119095570
  
Corresponding Affymetrix probe sets: GgaAffx.10490.1.S1_at (Chicken Array)   GgaAffx.10490.2.S1_at (Chicken Array)   GgaAffx.10490.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000026373
NCBI entrez gene - 427996     See in Manteia.
RefSeq - XM_004934661
RefSeq - XM_425566
swissprot - E1BR82
Ensembl - ENSGALG00000016382
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mbtps2ENSDARG00000057577Danio rerio
 MBTPS2ENSG00000012174Homo sapiens
 Mbtps2ENSMUSG00000046873Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001193  Membrane-bound transcription factor site-2 protease
 IPR001478  PDZ domain
 IPR008915  Peptidase M50


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis IEA
 biological_processGO:0036500 ATF6-mediated unfolded protein response IBA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)
ATF6 (ATF6-alpha) activates chaperones
CREB3 factors activate genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001252 CREB3L3 / cAMP responsive element binding protein 3 like 3 / Q68CJ9* / Q91XE9* / Cyclic AMP-responsive element-binding protein 3-like protein 3 Processed cyclic AMP-responsive element-bindi...  / reaction
 ENSGALG00000041687 SREBF2 / sterol regulatory element binding transcription factor 2 / Q12772* / Q3U1N2* / sterol regulatory element binding factor 2*  / reaction
 ENSGALG00000032278 ATF6 / activating transcription factor 6 / F6VAN0* / P18850* / Cyclic AMP-dependent transcription factor ATF-6 alpha Processed cyclic AMP-dependent transcription factor ATF-6 alpha*  / reaction






 

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