ENSDARG00000060094


Danio rerio

Features
Gene ID: ENSDARG00000060094
  
Biological name :ptgis
  
Synonyms : F1RE08 / prostaglandin I2 (prostacyclin) synthase / ptgis
  
Possible biological names infered from orthology : O35074 / prostaglandin I2 synthase / Q16647
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 46568119
Gene end: 46589726
  
Corresponding Affymetrix probe sets: Dr.10379.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000078769
swissprot - F1RE08
ZFIN ID - ZDB-GENE-070116-1
Ensembl - ENSDARG00000060094
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTGISENSG00000124212Homo sapiens
 PtgisENSMUSG00000017969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cyp8b1 / cytochrome P450, family 8, subfamily B, polypeptide 1 / Q9UNU6* / cytochrome P450 family 8 subfamily B member 1*ENSDARG0000005306841
cyp8b2 / cytochrome P450, family 8, subfamily B, polypeptide 2 / CYP8B1* / Q9UNU6* / cytochrome P450 family 8 subfamily B member 1*ENSDARG0000009755640
cyp8b3 / cytochrome P450, family 8, subfamily B, polypeptide 3 / CYP8B1* / Q9UNU6* / cytochrome P450 family 8 subfamily B member 1*ENSDARG0000009755940
cyp7a1 / cytochrome P450, family 7, subfamily A, polypeptide 1 / P22680* / Q64505* / Cholesterol 7-alpha-monooxygenase * / cytochrome P450 family 7 subfamily A member 1*ENSDARG0000006901832
cyp7b1 / cytochrome P450, family 7, subfamily B, polypeptide 1 / O75881* / Q60991* / 25-hydroxycholesterol 7-alpha-hydroxylase * / cytochrome P450 family 7 subfamily B member 1*ENSDARG0000000885831
CR354540.1ENSDARG0000000405127
cyp39a1 / cytochrome P450, family 39, subfamily A, polypeptide 1 / Q9NYL5* / cytochrome P450 family 39 subfamily A member 1*ENSDARG0000001798222


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002403  Cytochrome P450, E-class, group IV
 IPR024204  Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
 IPR027286  Prostacyclin synthase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008116 prostaglandin-I synthase activity IDA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 24-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Nicotinamide salvaging
Eicosanoids
Sterols are 12-hydroxylated by CYP8B1
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009065 endothelial cell endothelial cell apoptotic process increased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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